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NCT Number: NCT07414693

Effect of Vitamin C on Length of Hospital Stay in Children With Severe Pneumonia

Severe pneumonia is a common and serious illness in young children and often requires hospital admission. This clinical trial aims to find out whether adding vitamin C to standard treatment can reduce the length of hospital stay in children under five years of age admitted with severe pneumonia.

The main question this study seeks to answer is:

Does giving vitamin C along with routine treatment help children with severe pneumonia recover faster and go home earlier compared to standard treatment alone?

In this study, 90 children aged 2 to 59 months who are admitted to the Children's Hospital Multan with severe pneumonia will take part. Severe pneumonia is defined by fast breathing, fever, cough, and one or more danger signs such as difficulty feeding, repeated vomiting, seizures, bluish discoloration of lips, or noisy breathing. Children with chronic lung disease or weakened immunity will not be included.

After parental consent, children will be randomly divided into two groups. One group will receive standard treatment only, which includes oxygen therapy and intravenous antibiotics according to hospital protocol. The second group will receive the same standard treatment plus a daily dose of vitamin C. Neither group will receive any experimental or unapproved therapy.

Researchers will closely monitor each child's recovery, including improvement in breathing rate, temperature, oxygen levels, and overall clinical condition. The child will be discharged when the treating physician determines that recovery criteria are met. The number of days spent in the hospital from the start of treatment until discharge will be recorded.

By comparing the average hospital stay between the two groups, this study aims to determine whether vitamin C is a useful and safe add-on treatment for severe pneumonia in young children. The findings may help improve care and reduce hospital stay for children with severe pneumonia in the future.

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Key information

Age range

2 month–59 month

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Children Hospital and Institute of Child Health

Multan Khurd, Punjab Province, 60000, Pakistan

Location status: Recruiting

Location contact

Ayesha F Assistant Professor, FCPS

CONTACT

[email protected]

+92 333 6163845

Muhammad S Principal Investigator, MBBS

CONTACT

[email protected]

+92 302 2513701

Muhammad S Principal Investigator, MBBS

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • presenting with severe pneumonia
  • ≤ 48-hours duration

Exclusion criteria

  • Congenital heart disease
  • Children with chronic respiratory illnesses i.e. Asthma, post tuberculosis bronchiectasis and cystic fibrosis
  • Immunosuppressed i.e. primary immune deficiency, malignancy, on steroid therapy

Treatment and study plan

Antibiotics administration

Drug

Antibiotics Plus supportive care including oxygen inhalation, intravenous rehydration, and antipyretics

Vitamin C

Drug

Standard care (oxygen inhalation, intravenous rehydration, and antipyretics) plus Vitamin C: 200-mg (2 cc = 4 dropper, should be mixed in milk or water) once a day

Other names: Ascorbic acid

Primary outcomes

  1. Hospital Stay

    Time frame: From randomization to hospital discharge, assessed at discharge (up to 30 days).

    Duration of Hospital Stay in days

Study contacts

Contact information is provided by the study sponsor or research team.

Ayesha F Assistant Professor, FCPS

CONTACT

[email protected]

+92 333 6163845

Muhammad S Principal Investigator, MBBS

CONTACT

[email protected]

+92 302 2513701

Sponsors and collaborators

Lead sponsor

Children's Hospital and Institute of Child Health, Multan

Other Gov

Registry information

Official study title

Efficacy of Vitamin C as an Adjunct to Standard Treatment in Severe Pneumonia in Children Under Five Years of Age: A Clinical Comparison

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 17, 2026
Registry last updated
Feb 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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