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NCT Number: NCT07556029

Optimal Protein Intake to Maximize Whole-Body Protein Balance in Healthy Adults

The purpose of this study is to assess the optimal protein intake to maximize whole-body protein net balance in healthy adults. In a randomized, double-blinded, crossover design, 12 young, healthy adult males and females aged 18-35 years, will consume a test diet consisting of free amino acid mixtures based on milk protein that vary in protein content 7 separate acute metabolic trials. The main study endpoint is optimal protein intake based on the lowest protein intake that maximizes whole-body protein net balance.

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Key information

Conditions

Protein Metabolism

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged between 18-35 years
  • BMI between 18.5-30 kg/m2
  • Healthy, recreationally active (exercise at least once per two weeks and a maximum of four days per week)
  • No physical limitations (i.e., able to perform all activities associated with daily living independently)

Exclusion criteria

  • Smoking
  • Diagnosed musculoskeletal disorders
  • Use of any medications known to affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications)
  • Chronic use of gastric acid-suppressing medication or anti-coagulants
  • Unstable weight over the last three months
  • Diagnosed GI tract disorders or diseases
  • Blood donation in the past 2 months
  • Females: pregnancy

Treatment and study plan

Amino Acid

Dietary Supplement

Test diet consisting of free amino acid mixtures based on milk protein.

Primary outcomes

  1. Optimal protein intake

    Time frame: From enrolment through to study completion, minimum 7 weeks

    The optimal protein intake to maximize whole-body protein synthesis rates in healthy, young males and females based on the consumption of milk protein.

Study contacts

Contact information is provided by the study sponsor or research team.

Jorn Trommelen, PhD

CONTACT

[email protected]

+31 43 388 1617

Julia M Malowany, MSc

CONTACT

[email protected]

+31 43 388 1617

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Acronym: PAAKO

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Apr 29, 2026
Registry last updated
Apr 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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