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NCT Number: NCT06783075

Milk Vs Wheat Protein Intake to Maximize Whole-body Protein Synthesis Rates in Healthy Older Adults

Dietary protein intake is essential for tissue renewal and growth. Current recommendations for protein intake are based on studies using egg protein as reference protein. Egg protein is an animal-based protein with a high quality. Protein quality is determined by the composition of (essential) amino acids and digestibility. Therefore, different proteins have a different quality. Due to the environmental crisis, an increasing number of people consumes more plant-based proteins. These plant-based proteins often have a lower protein quality compared to animal-based proteins. Therefore, the aim of this study is to investigate whether optimal protein intake depend on protein quality. The optimal protein intake of an animal-based protein with a high quality (milk) will be compared to the optimal protein intake of a plant-based protein with a low quality (wheat).

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Key information

Conditions

Protein Metabolism

Age range

65 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Maastricht University Medical Center+

Maastricht, Limburg, Netherlands

Location contact

Loïs Reijnders

CONTACT

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged between 65-85 years
  • BMI between 18.5-30 kg*m^-2
  • Healthy, recreationally active (maximal one intensive exercise training per week)
  • No physical limitations (i.e., able to perform all activities associated with daily living independently)

Exclusion criteria

  • Smoking
  • Diagnosed musculoskeletal disorders
  • Use of any medications known to affect protein metabolism (i.e., corticosteriods, non-steroidal anti-inflammatories)
  • Chronic use of gastic acid-suppressing medication or anti-coagulants
  • Unstable weight over the last 3 months
  • Diagnosed GI tract disorders or diseases
  • Blood donation in the past 2 months

Treatment and study plan

Milk

Other

Drink containing amino acids in the composition of milk protein

WHEAT

Other

Drink containing amino acids in the composition of wheat protein

Primary outcomes

  1. Differences in protein intake to maximize whole-body protein synthesis rates in older adults based on consumption of milk protein or wheat protein

    Time frame: From enrollment to the end of the study at 7 weeks

Secondary outcomes

  1. Estimated Average Requirement (EAR) to maximize whole-body protein synthesis rates in healthy older adults based on milk protein

    Time frame: From enrollment to the end of the study at 7 weeks

  2. The Recommended Daily Allowance (RDA) to maximize whole-body protein synthesis rates in older adults based on milk protein

    Time frame: From enrollment to the end of the study at 7 weeks

  3. The Estimated Average Requirement (EAR) to maximize whole-body protein synthesis rates in older adults based on wheat protein

    Time frame: From enrollment to the end of the study at 7 weeks

  4. The Recommended Daily Allowance (RDA) to maximize whole-body protein synthesis rates in older adults based on wheat protein

    Time frame: From enrollment to the end of the study at 7 weeks

Study contacts

Contact information is provided by the study sponsor or research team.

Luc van Loon

CONTACT

[email protected]

0031 43 388 1743

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Acronym: Plant-IAAO

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Jan 20, 2025
Registry last updated
Jan 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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