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Enrolling by Invitation

NCT Number: NCT06784037

Optimal Positive End-Expiratory Pressure in Robotic-Assisted Thoracic Surgery Without Capnothorax

The aim of this study is to assess the impact on lung mechanics during robotic lung resection when no capnothorax is used.

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Key information

Conditions

Robotic Thoracic Surgery Mechanical Ventilation Positive End Expiratory Pressure (PEEP)

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital Clinic Barcelona

Barcelona, Catalonia, 08036, Spain

About this study

Assess the improvement of oxygenation, ventilation and lung mechanics in patients ventilated with individualized PEEP without capnothorax. PEEP requirement and lung mechanics without capnothorax will be compared with a historical cohort population of robotic surgery with capnothorax.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing uniportal robotic lung resection under no capnothorax

Exclusion criteria

  • Refusal to participate
  • Contraindications to recruitment maneuvers

Treatment and study plan

Primary outcomes

  1. Respiratory airway pressures

    Time frame: During intra-operative mechanical ventilation (4 hours)

    Respiratory airway pressures (peak pressure, plateau pressure and PEEP in cmH2O)

  2. Respiratory rate

    Time frame: During intra-operative mechanical ventilation (4 hours)

    Respiratory rate (in cycles per minute)

  3. Respiratory system compliance

    Time frame: During intra-operative mechanical ventilation (4 hours)

    Respiratory pressures measurement will be combined to obtain respiratory system compliance.

    Respiratory system compliance = (plateau pressure-PEEP) / respiratory tidal volume (expressed in cmH2O/mL)

Secondary outcomes

  1. Arterial blood gas parameters: pO2

    Time frame: During intra-operative mechanical ventilation (4 hours)

    pO2 in mmHg in arterial blood gas sample

  2. Arterial blood gas parameters: pCO2

    Time frame: During intra-operative mechanical ventilation (4 hours)

    pCO2 in mmHg in arterial blood gas sample

  3. Arterial blood gas parameters: pH

    Time frame: During intra-operative mechanical ventilation (4 hours)

    pH of arterial blood gas samples (no unit can be applied)

  4. Arterial blood gas parameters: sodium bicarbonate

    Time frame: During intra-operative mechanical ventilation (4 hours)

    Arterial blood sample sodium bicarbonate concentration (in mmol/L)

  5. Arterial blood gas parameters: base excess

    Time frame: During intra-operative mechanical ventilation (4 hours)

    Base excess in arterial blood gas samples in mEq/L

Sponsors and collaborators

Lead sponsor

Hospital Clinic of Barcelona

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jan 20, 2025
Registry last updated
Jan 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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