University of Michigan
Ann Arbor, Michigan, 48109, United States
NCT Number: NCT05519345
The purpose of this study is to examine if the changes in corticospinal function that accompany ACL reconstruction can be improved through a form of mental coaching and encouragement, known as operant conditioning.
Looking for future studies?
Notify Me14 year–45 year
All sexes
Interventional
Not applicable
Ann Arbor, Michigan, 48109, United States
It is theorized reduced corticospinal excitability contributes to quadriceps dysfunction after knee injury and joint disease. Current rehabilitation does not directly target the alterations in corticospinal excitability, which may limit recovery. Operant conditioning is an emerging approach capable of increasing corticospinal excitability by directly targeting the corticospinal pathways. However, it remains to be determined whether operant conditioning of the corticospinal pathway may improve corticospinal function after knee trauma. Therefore, this study will evaluate the ability of operant up-conditioning of the corticospinal pathway to improve corticospinal function after ACL reconstruction.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Active encouragement and feedback to increase motor evoked response during stimulation.
Absence of active encouragement and feedback to increase motor evoked response when stimulated.
Time frame: Baseline (before the start of the intervention) and post-intervention (approximately 2 weeks after baseline)
Corticospinal excitability will be measured using transcranial magnetic stimulation at baseline and post-intervention and will be compared between groups.
Time frame: Baseline (before the start of the intervention) and post-intervention (approximately 2 weeks after baseline)
Isometric quadriceps strength will be measured using an isokinetic dynamometer. Quadriceps strength will be measured prior to the intervention and immediately following the intervention.
Time frame: Baseline (before the start of the intervention) and post-intervention (approximately 2 weeks after baseline)
Voluntary activation will be measured using an electrical superimposition technique. Voluntary activation will be measured prior to the intervention and immediately following the intervention.
University of Michigan
Other
Conditioning Brain Responses for Modulating Corticospinal Excitability After ACL Reconstruction
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT07681193
ACL Injury, ACL Tear
Chapel Hill, North Carolina, United States
View Trial DetailsNCT04914689
Anterior Cruciate Ligament Injuries, Knee Injuries
Charlotte, North Carolina, United States
View Trial DetailsNCT04162613
Anterior Cruciate Ligament Injuries, Knee Injuries
Umeå, Sweden
View Trial DetailsNCT07540715
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Reconstruction
Konya, Turkey (Türkiye)
View Trial Details