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NCT Number: NCT06928727

Ocular Characteristics in Patients With Craniosynostosis

Craniosynostosis are cranial deformations due to the premature closure of one or more cranial sutures. These deformations affect approximately one in 2.500 births. In most cases, craniosynostoses are isolated with unknown (non syndrome). On the other hand, 20% of these deformations are associated with other concentration (syndrome).

Craniosynostosis has morphological (associated dysmorphism) and functional (growth conflict between the skull and the brain) repercussions. Ophthalmological disorders are frequent: refractive disorders, oculomotor disorders, optic nerve damage, sensory damage.

This retrospective study aims to describe the ocular clinical characteristics associated with craniosynostosis in patients followed at the Amiens University Hospital.

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Key information

Conditions

Craniosynostosis Amblyopia Bone Diseases Bone Diseases, Developmental Brain Diseases Central Nervous System Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Cranial Nerve Diseases Craniofacial Abnormalities Craniosynostoses Dysostoses Eye Diseases Intracranial Hypertension Musculoskeletal Abnormalities Musculoskeletal Diseases Nervous System Diseases Neurologic Manifestations Ocular Motility Disorders Pathological Conditions, Signs and Symptoms Sensation Disorders Signs and Symptoms Strabismus Synostosis Vision Disorders

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU Amiens

Amiens, 80054, France

Location status: Recruiting

Location contact

Mathilde Singlas, MD

CONTACT

[email protected]

33+322089200

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of craniostenosis

Exclusion criteria

  • Posterior plagiocephalia

Treatment and study plan

Primary outcomes

  1. Rate of strabismus and amblyopia

    Time frame: 6 months

    Rate of strabismus and amblyopia

Secondary outcomes

  1. Rate of intracranial hypertension

    Time frame: 6 months

    Rate of intracranial hypertension

Study contacts

Contact information is provided by the study sponsor or research team.

Tran Thi Ha Chau, Pr

CONTACT

[email protected]

33+322089224

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: COPACA

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Apr 15, 2025
Registry last updated
Feb 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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