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OpenTrials
Recruiting

NCT Number: NCT05785182

OCT in Open Fracture and Infected Fracture

This is a pilot prospective, observational study of patients with open or infected fracture evaluating the feasibility and acceptability of OCT, a light-based imaging modality that requires no drug or contrast agent.

Recruiting

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Key information

Conditions

Trauma Injury Accidental Injuries Fracture Infection Fractures, Bone Fractures, Open Open Fracture Trauma Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 years or older
  • Open fracture
  • Fracture Related Infection

Exclusion criteria

  • Metatarsal fractures

Treatment and study plan

Open Fracture

Procedure

Patients 18 years of age or older with open fracture. Provision of informed consent.

Infected Fracture

Procedure

Patients 18 years of age or older with infected fracture. Provision of informed consent.

Primary outcomes

  1. Feasibility and acceptability of OCT imaging

    Time frame: 36 months

    The primary objective of this work is to demonstrate feasibility, acceptability, and preliminary effectiveness of Optical Coherence Tomography (OCT) to image bacteria and biofilm.

    Data will be analyzed accordingly: The association between optical imaging parameters (particularly around biofilm and bacterial contamination) and (1) surgical wound severity and (2) development of infection or treatment failure for infection.

Study contacts

Contact information is provided by the study sponsor or research team.

Devin S Mullin

CONTACT

[email protected]

603-650-6032

Holly B Symonds

CONTACT

[email protected]

603-653-9440

Sponsors and collaborators

Lead sponsor

Dartmouth-Hitchcock Medical Center

Other

Collaborators

  • Dartmouth College

Registry information

Official study title

Optical Coherence Tomography Imaging to Visualize Bacteria or Biofilm on Hardware, Bone and Soft Tissue in Open Fracture and Infected Fracture

Important dates

Study start
2023
Primary completion
2026
Study completion
2027
First posted
Mar 27, 2023
Registry last updated
Jul 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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