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NCT Number: NCT06050369

Objective Characterizatoion of Repetitive Behaviors

Introduction:

Repetitive behaviors (RB) constitute a broad range of symptoms across different psychiatric/neurologic disorders. The most famous are stereotypies (found in autism), compulsions (found in obsessive-compulsive-disorder, OCD) and tics (found in Gilles de la Tourette syndrome, GTS). For some patients, it is sometime difficult to distinguish the nature of the repetitive behaviors presented, however this distinction is crucial in order to chose the appropriate treatment.

Aim:

In our study, the investigators will try to define electrophysiological and accelerometric marker of both OCD and tics to allow objective distinction between both tics and compulsions.

Method:

Subjects: Both OCD and GTS patients will be recruited, 25 patients in each group.

Protocol: our study protocol will involve two step: a step in laboratory, another step at patient home.

* first step: both patients group will be recorded through a high density EEG and a portative EEG while doing a task of symptom provocation. Then they will get an anatomical MRI for source recontruction. Finally, the patients will have to mimic their symptom while wearing an accelerometer (a smartwatch). * second step: both patient groups will be recorded at home through a portative EEG while tagging their symptom through a smartwatch (also used for accelerometry). After the recording, the patients will keep the smartwatch for 2 weeks, still tagging their sympoms (compulsions or tics).

Recruiting

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Key information

Age range

15 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpital Albert Chenevier, Créteil, France

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • To be more of 15 years old or less than 65 years old
  • To suffer from OCD and/or GTS (depressive, anxious and attention deficit hyperactivity disorder (ADHD) comorbidities are accepted)
  • To be registered to the french social security (or something equivalent)
  • To give written consent to participate to the research
  • To have contraception for women participants (or to not have any sexual activity)

Exclusion criteria

  • Patients with any other psychiatric disorders than those mentioned in the inclusion criteria
  • Patients with any other neurological disorder than GTS
  • Patients who are not able to take decisions for themselves
  • Pregnant women
  • Patients not allowed to get MRI due to contraindication
  • Patients not speaking french

Treatment and study plan

EEG

Device

Recording, from the scalp, the electrophysiological activity of the brain.

Other names: Electroencephalogram

MRI

Device

Get the anatomical shape of the brain.

Other names: magnetic resonance imaging

Primary outcomes

  1. modification of power (μV2) in EEG frequencies before compulsions in Obsessive-Compulsive Disorder patients

    Time frame: one year

    change in the power EEG frequencies in OCD patients before compulsions EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations

  2. modification of power (μV2) in EEG frequencies before tics in Gilles de la Tourette patients

    Time frame: one year

    change in the power of EEG frequencies in GTS patients before tics EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations

Secondary outcomes

  1. Difference in power (μV2) in EEG frequencies between obsessive-compulsive disorder patients and Gilles de la Tourette patients

    Time frame: One year and a half

    Difference in the power in the EEG frequencies between obsessive-compulsive disorder patients and Gilles de la Tourette patients EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations

  2. percentage (%) of compulsions and tics detected by accelerometer

    Time frame: One year and a half

    percentage of compulsions and tics detected by accelerometer

  3. Correlation of EEG frequency power (arbitrary units) detected before compulsions and scores get with clinical scales (Y-BOCS)

    Time frame: One year and a half

    Correlation between power in EEG frequencies and Y-BOCS score get by each individual patients Y-BOCS = Yale-Brown Obsessive-Compulsive Scale; Scores range from 0 to 40 with 40 corresponding to the maximum severity of symptoms

  4. Correlation between number of compulsions detected by accelerometer and Y-BOCS scores get by obsessive-compulsive patients

    Time frame: One year and a half

    Correlation between number of compulsions detected by accelerometer and Y-BOCS scores get by obsessive-compulsive patients Y-BOCS = Yale-Brown Obsessive-Compulsive Scale; Scores range from 0 to 40 with 40 corresponding to the maximum severity of symptoms

Study contacts

Contact information is provided by the study sponsor or research team.

Hugues LAMOTHE, MD

CONTACT

[email protected]

+33149813195

Luc MALLET, MD

CONTACT

[email protected]

+33157274000

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Registry information

Official study title

Actimetric and Electrophysiological Analyses of Repetitive Behaviors (Tics and Compulsions)

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Sep 22, 2023
Registry last updated
Feb 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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