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OpenTrials
Completed

NCT Number: NCT02574039

Oat Phenolics Bioavailability

A diet rich in whole grain is inversely associated with cardiovascular disease risk and this benefit could be partly attributed to the phenolic acid content of whole grains. The exact absorption, metabolism and excretion of whole grain phenolic acids, however, is not fully understood. In a small human intervention trial, the investigators will investigate to what extent phenolic acids from whole grain oats are absorbed, excreted in urine and how they are metabolised.

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Key information

Conditions

Healthy Choroid Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Eye Diseases Eye Diseases, Hereditary Genetic Diseases, Inborn Gyrate Atrophy Uveal Diseases

Age range

25 year–65 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Department of Food and Nutritional Sciences

Reading, Berkshire, RG6 6AP, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Males
  • 25 to 65 years old

Exclusion criteria

  • Allergies to oats
  • Parallel participation in another research project
  • Having flu vaccination or antibiotics within 3 months of trial start
  • Taking food supplements within 3 months of trial start
  • Past or existing medical history of vascular disease, diabetes, hepatic, renal, gastrointestinal, haematological, neurological, thyroidal disease or cancer

Treatment and study plan

Oat bran

Dietary Supplement

66g oat bran made up in 350ml skimmed milk

Refined grain

Dietary Supplement

refined grain product and 350ml skimmed milk

Primary outcomes

  1. Change from baseline in phenolic acid metabolite excretion

    Time frame: Baseline and 48 hours

Sponsors and collaborators

Lead sponsor

University of Reading

Other

Collaborators

  • PepsiCo Global R&D

Registry information

Official study title

Absorption, Metabolism and Excretion of Oat Phenolic Acids in Healthy Men.

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Oct 12, 2015
Registry last updated
Oct 12, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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