Novel Synthetic T2W MR Imaging and Spin Parameter Mapping Techniques for Screening Prostate Cancer

PRIMARY OBJECTIVE:

I. To determine whether the image quality of the novel 3-dimensional (3D) T2-weighted imaging (T2W) synthetic imaging technique without endorectal coil is comparable to the 2-dimensional (2D) T2W imaging technique without endorectal coil.

SECONDARY OBJECTIVE:

I. To evaluate the qualitative diagnostic quality of the T2W images provided by the novel 3D technique, as determined by subjective scoring by experienced readers.

EXPLORATORY OBJECTIVE:

I. To investigate the feasibility of novel 3D synthetic imaging and multi-spin parameter mapping technique of prostate for the detection of clinically significant prostate cancer (csPCa).

OUTLINE:

Patients undergo 3D MRI imaging over 15 minutes with standard of care MRI or at a separate time.

Inclusion criteria

• Male, age >= 18
• Untreated, biopsy-proven with intermediate and high-risk adenocarcinoma of the prostate
• Patient is being considered for curative-intent treatment with radical prostatectomy
• Patient has provided written informed consent for participation in this trial
• Patient should be eligible for scanning on a 3T magnet

Exclusion criteria

• Low-risk adenocarcinoma of prostate
• Any prior therapy for prostate cancer
• A history of other active malignancy within the last 2 years
• Prostate cancer with significant sarcomatoid, spindle cell, or neuroendocrine small cell components
• Cardiac pacemaker
• Orthopedic hardware in the pelvis and spine
• Claustrophobia