Non-hypovascular Solid Pancreatic Lesions: Role of EUS

Vascular pattern of solid pancreatic lesions (SPLs) has been investigated by different abdominal imaging modalities and by contrast-enhanced endoscopic ultrasonography (CE-EUS). Compared with surrounding pancreatic parenchyma three different patterns have been described: hypo-, iso-, and hypervascular. The majority of SPLs are hypovascular, and the diagnostic relevance of hypoenhanced pattern to predict pancreatic adenocarcinoma (PDAC) is well established. Differently, iso- and hypervascular pattern is not specific and can be expressed by several SPLs, with different clinical behavior and management. To date, poor is know about the role of EUS in differential diagnosis of non-hypovascular SPLs and features associated with malignancy.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Solid Pancreatic Neoplasms Endoscopic Ultrasound

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Stefano Francesco Crinò

Verona, VR, 37138, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Presence of one or more solid pancreatic lesions preliminary evaluated by contrast-enhanced computed tomography (CE-CT) and/or contrast enhanced magnetic resonance imaging (CE-MRI) reporting a non-hypovascular contrast pattern (e.g., iso- or hypervascular).

Exclusion criteria

Patients with associated chronic pancreatitis features (e.g., pancreatic calcifications)
Lesion with hypovascular pattern at CE-EUS.
Lesion not found or non pancreatic at EUS.
Patients refusing to be included in the study

Treatment and study plan

Endoscopic ultrasound-fine needle biopsy

Diagnostic Test

Patients with non-hypovascular solid pancreatic lesion undergo endoscopic ultrasound-fine needle biopsy

Primary outcomes

Upstream dilation of the main pancreatic duct

Time frame: 6 months

Percentage of cases with upstream dilation of main pancreatic duct will be recorded.
Vascular pattern (iso or hypervascular)

Time frame: 6 months

Percentage of cases with iso-vascular or hyper-vascular pattern will be recorded.
Lesion borders (smooth or irregular)

Time frame: 6 months

Percentage of cases with smooth or irregular borders will be recorded.

Sponsors and collaborators

Lead sponsor

Azienda Ospedaliera Universitaria Integrata Verona

Other

Registry information

Official study title

Role of EUS in Differential Diagnosis and Malignancy Prediction of Non-hypovascular Solid Pancreatic Lesions: A Prospective Observational Study

Acronym: LE-VASC

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2019
First posted: Nov 13, 2018
Registry last updated: May 7, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting