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Enrolling by Invitation

NCT Number: NCT06704867

High Flow Nasal Cannula Compared to Standard Oxygen for Endoscopic Ultrasound

The purpose of the study is to evaluate the use of high flow nasal cannula versus standard oxygen therapy for high-risk patients undergoing endoscopy procedures.

Enrolling by Invitation

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Key information

Conditions

Endoscopic Ultrasound

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mayo Clinic

Rochester, Minnesota, 55901, United States

About this study

Patients with a higher BMI are at greater risk for lower oxygen levels which can delay the endoscopy procedure. This research is being conducted to find out if high risk patients will have a shorter recovery time and improved procedural conditions with a high flow nasal cannula versus standard oxygen therapy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients age 18 years and older who present to Gonda 2 procedural area for Endoscopic ultrasound (EUS) with or without endoscopy (EGD)/biopsy/tissue sampling. with BMI ≥ 35 kg/m2 (BMI within the past 6 months in electronic medical records or at current procedure) who are able to consent will be approached for potential enrollment.

Exclusion criteria

  • Need for general anesthesia for the procedure instead of the standard monitored anesthesia care.
  • Patients undergoing combined procedure: Therapeutic EUS/combined procedures including EUS/ERCP, EUS/colonoscopy
  • Patients on home oxygen therapy, or the diagnosis of "severe COPD"
  • Patients with existing tracheostomy
  • Inpatients undergoing EUS
  • Inability to consent
  • Cognitive impairment
  • Blocked nasal passages
  • Trauma/previous surgery to the nasopharynx
  • Irregularities of the nose, face, or airway such that HFNC cannot be properly fitted

Treatment and study plan

High Flow Nasal Cannula

Other

Subjects undergoing endoscopic ultrasound will receive high flow nasal cannula during the procedure

Primary outcomes

  1. Decrease recovery time

    Time frame: 4 hours

    Time measured in minutes for participants to enter post anesthesia care until the nurse marks "ready for discharge" in the medical record.

Secondary outcomes

  1. Improve procedural conditions

    Time frame: 1 hour

    Decreased number of times the procedure is paused or delayed.

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Collaborators

  • Fisher and Paykel Healthcare

Registry information

Official study title

High Flow Nasal Cannula Compared to Standard Oxygen Therapy for Endoscopic Ultrasound Procedure in High Risk Patients on Recovery Time and Procedural Conditions

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Nov 26, 2024
Registry last updated
Jan 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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