Nitrate - Clopidogrel - Acute Coronary Syndrome

This study aims to investigate whether intravenous nitrate given during non-ST-elevation myocardial infarction (non-STEMI) affects the platelet inhibition of clopidogrel.

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Key information

Conditions

Acute Coronary Syndromes Acute Coronary Syndrome Cardiovascular Diseases Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Bursa Yüksek İhtisas Hastanesi

Bursa, 16340, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

diagnosed with non-STEMI
Patients aged 18 to 75 years
positive troponin levels,
blood pressure above 120/70 mmHg

Exclusion criteria

Hemodynamically unstable and requiring urgent intervention,
ST elevation on electrocardiography, atrial fibrillation,
recurrent angina,
use of narcotic analgesics (e.g., morphine), nitrates and glycoprotein IIb/IIIa inhibitors during hospitalization,
history of coronary artery bypass graft (CABG) surgery,
active infection,
uncontrolled hypertension,
diabetes, cerebrovascular accident, Use P2Y12 inhibitor, proton pump inhibitor, oral anticoagulant, statin, CYP enzyme-inducing or inhibiting drugs at the time of admission,
active systemic disease (e.g., malignancy, thyroid disorders chronic inflammatory diseases, liver dysfunction),
left ventricular systolic dysfunction (ejection fraction <50%),
glomerular filtration rate <60 mL/min/1.73m2,
allergy to ASA or clopidogrel, coagulopathy,
platelet counts below 100,000/μl and hematocrit levels below 29%, or exceeding 52%.

Treatment and study plan

Primary outcomes

Platelet Reactivity Unit level

Time frame: 48 hours

Platelet Reactivity Unit <208

Sponsors and collaborators

Lead sponsor

Bursa Postgraduate Hospital

Other

Registry information

Official study title

Impact of Intravenous Nitrate Treatment on Antiplatelet Effects of Clopidogrel in Acute Coronary Syndrome Patients: A Pilot Study

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2024
First posted: Mar 17, 2025
Registry last updated: Mar 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed