Skip to main content
OpenTrials
Completed

NCT Number: NCT03675100

Neurotrophic Factors, Tight Junction Proteins, and Cytokines in IBS

To evaluate the role of neurotrophic factors (NGF, GDNF, TRPV-1), to quantity tight junction proteins (ZO-1, occludin, claudin) and cytokines (IL-8, TNF-a, IL-1b) in the colonic mucosa of IBS patients and also clarify sex differences in the pathophysiology of IBS.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Irritable Bowel Syndrome Behavior Coitus Colonic Diseases Colonic Diseases, Functional Digestive System Diseases Gastrointestinal Diseases Intestinal Diseases Pathophysiology Sexual Behavior Tight Junction Alteration

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 463-707, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Control group Those who were between 18 and 80 years old and did not have any abnormalities in colonoscopy
  • Irritable bowel syndrome group Patients who diagnosed as irritable bowel syndrome according to the ROME III criteria

Exclusion criteria

  • history of IBD
  • abdominal operation
  • severe systemic disease
  • malignancy,

Treatment and study plan

colonoscopic mucosal biopsy

Procedure

colonoscopic mucosal biopsy was undertaken for every participant

Primary outcomes

  1. NGF, GDNF, and TRPV-1 mRNA expression of colonic mucosa

    Time frame: up to 24 weeks

    real-time qPCR

Secondary outcomes

  1. ZO-1, Occludin, and Claudin mRNA expression of colonic mucosa

    Time frame: up to 24 weeks

    real-time qPCR and Western blot

  2. IL-8, TNF-a, and IL-1b mRNA expression of colonic mucosa

    Time frame: up to 24 weeks

    real-time qPCR

Sponsors and collaborators

Lead sponsor

Seoul National University Bundang Hospital

Other

Registry information

Official study title

Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex

Important dates

Study start
2009
Primary completion
2019
Study completion
2019
First posted
Sep 18, 2018
Registry last updated
Mar 24, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.