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OpenTrials
Completed

NCT Number: NCT00742118

Effects of the Soluble Mediators of Mastocytes on the Intestinal Epithelial Barrier and of the Enteric Nervous System During the Syndrome of the Irritable Bowel

Patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. The investigators aimed to investigate:

1. paracellular permeability in colonic biopsies of IBS patient 2. the ability of soluble factors from colonic biopsies to reproduce in vitro these alterations

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Key information

Conditions

Irritable Bowel Syndrome Colonic Diseases Colonic Diseases, Functional Digestive System Diseases Gastrointestinal Diseases Intestinal Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of gastroenterology, Hopital Archet 2

Nice, 06002, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients needing coloscopy

Exclusion criteria

  • Disrupted coagulation results
  • Cancer even healed
  • Known food allergy.
  • Alcohol consumption >30g/day

Treatment and study plan

Colic biopsies

Procedure

colic biopsies and analysis

Other names: endoscopic biopsy

Primary outcomes

  1. Para-cellular permeability

    Time frame: at time=0

  2. Gap junction protein expression

    Time frame: at time=0

  3. Inflammation molecule expression

    Time frame: at time=0

  4. Digestive discomfort degree

    Time frame: at time=0

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Collaborators

  • Fondation de l'Avenir

Registry information

Official study title

Effects of the Soluble Mediators of Mastocytes on the Intestinal Epithelial Barrier and of the entérique Nervous System During the Syndrome of the Irritable Bowel

Important dates

Study start
2008
Primary completion
2014
Study completion
2016
First posted
Aug 27, 2008
Registry last updated
Jun 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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