Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07233941

Neuropsychological Profile Characterization in Patients With Migraine: Cognitive Functioning and Psychological Variables

The overall objective is to define the neuropsychological profile of patients with migraine and evaluate its association with: psychological outcome measures (anxiety-depressive symptoms, pain catastrophizing, excessive worry, and coping strategies); the clinical profile of migraine; the prodromal, ictal, or interictal phase of the migraine attack; pharmacological therapy; and detoxification treatment in patients with migraine associated with medication overuse headache.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Migraine Brain Diseases Central Nervous System Diseases Cognition Disorders Cognitive Dysfunction Headache Disorders Headache Disorders, Primary Mental Disorders Migraine Disease Migraine Disorders Nervous System Diseases Neurocognitive Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Written informed consent.
  • Patients aged between 18 and 65 years.
  • Diagnosis of migraine according to the International Classification of Headache Disorders (ICHD-3) criteria.
  • Patients with a history of migraine for at least one year, to ensure the stability of the condition.
  • Stability of ongoing treatment for at least 3 months at baseline.
  • Understanding of the Italian language.

Exclusion criteria

  • Severe medical or psychiatric conditions (depression, schizophrenia, psychosis) documented by specific previous diagnoses.
  • A history of alcohol or drug abuse.
  • Primary sensory deficits.

Treatment and study plan

Primary outcomes

  1. Cognitive functioning

    Time frame: 2 years

    Neuropsychological test scores in migraine patients and proportion of participants with cognitive performance significantly different from age- and education-adjusted normative data.

Secondary outcomes

  1. Cognitive functions and psychological, clinical aspects

    Time frame: 2 years

    Correlation between cognitive performance scores and validated measures of anxiety/depression, pain catastrophizing, worry, coping strategies, headache-related impact and disability, and sleep quality in migraine patients.

  2. Cognitive functions and different pharmacological treatments

    Time frame: 2 years

    Differences in cognitive test performance scores among groups of migraine patients receiving different pharmacological treatments

  3. Cognitive functions and medication overuse headache

    Time frame: 2 years

    Change in cognitive test performance scores from pre-detoxification to post-detoxification treatment in patients with migraine and medication overuse headache.

  4. Cognitive functions in the different phases of migraine

    Time frame: 2 years

    Comparison of cognitive test performance scores between ictal and interictal migraine phases and across different durations of disease.

Sponsors and collaborators

Lead sponsor

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Other

Registry information

Acronym: CogMIG

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Nov 18, 2025
Registry last updated
Feb 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.