Neuropsychological Impact of Hospitalization on Intubated, Ventilated and Sedated ICU Patients

The secondary objectives of this study are:

A. To study the potential links between cognitive impairment and quality of life 4 months after discharge from the Intensive Care Unit.

B. To study the associations between variables measured during hospitalization. Is there "clustering" among certain symptoms during hospitalization?

C. To study the associations between variables measured at two and four months after ICU discharge. Is there clustering among these symptoms?

D. To study potential risk factors for cognitive problems at 4 months after ICU discharge.

E. If objective C determines the presence of clusters, is the presence / absence of these clusters related to the variables (or clusters of variables) measured during hospitalization?

F. To study potential risk factors for poor quality of life at 4 months:

Inclusion criteria

• The patient (or his/her "trusted person") must have given his/her informed and signed consent
• The patient must be insured or beneficiary of a health insurance plan
• The patient is available for a telephone interview at 2 months after ICU discharge, and for a follow-up visit at 4 months after ICU discharge
• Patient admitted to the ICU and intubated and ventilated for at least 48 hours

Exclusion criteria

• The patient is currently participating in or has participated in another study (within the past 3 months) that might influence the results of the current study
• The patient is under judicial protection, under tutorship or curatorship
• The patient refuses to sign the consent
• It is impossible to correctly inform the patient
• The patient is pregnant, parturient, or breastfeeding
• The patient has a contra-indication for a treatment used in this study
• Patient admitted to intensive care with sedation started for more than 24 hours
• Patient with neurological or psychiatric (cognitive) disorders
• Patient admitted for cardiac arrest
• Patient admitted for stroke
• Patient admitted for cervical trauma > C6
• Patient presenting with tracheotomy accompanied by long-term mechanical ventilation
• Moribund patient or with little hope of survival beyond 48 hours
• Patients for whom a limitation or termination of care is considered
• McCabe Score = 0
• Knauss Scale = C or D