Neuroimaging Effects of Cognitive Behavioral Therapy in Fibromyalgia

Investigators propose to use fMRI (functional Magnetic Resonance Imaging) to study CNS pain processing during the anticipation and experience of acute pain in individuals with FM and healthy controls. Investigators will recruit patients who are diagnosed with FM as well as healthy controls. After the baseline visit, FM participants will be randomly assigned into the CBT or control condition (Education). Overall, FM Participants will attend 8 treatment visits, and 6 assessment visits (two at baseline, one at mid-treatment, two at the end of treatment, and one at 6 months post-treatment). These assessment visits include a total of 3 fMRI sessions (at baseline, mid-treatment, and end of treatment). Healthy Controls will undergo the same baseline procedures as the FM subjects but will not attend any of the treatment or follow up assessment visits. Findings from this research will provide important information about catastrophizing's CNS (Central Nervous System) correlates.

Inclusion criteria

for FM patients:

• Aged 18-65
• Female
• Have a clinical diagnosis of fibromyalgia and meet the Wolfe et al. 2011 research criteria for fibromyalgia
• On stable doses of medication prior to entering the study and agree not to change medications or dosages (or CAM treatments) during the trial
• Right-handed
• Baseline pain intensity of at least 4/10 on average and pain report for at least 50% of days
• Able to provide written consent

Exclusion criteria

for FM:

• Comorbid acute pain condition
• Comorbid chronic pain condition that is rated by the subject as more painful than fibromyalgia
• Current use of prescription stimulant medications (e.g., modafinil)
• Routine use of substances of abuse
• Certain condition that interfere with Quantitative Sensory Testing (QST) and/or fMRI procedures (e.g., Peripheral neuropathy, implanted ferrous metal, claustrophobia etc) or/and any impairment, activity or situation that could prevent satisfactory completion of the study protocol

Inclusion criteria

for Healthy Control Participants

• Aged 18-65
• Female
• Right-handed
• Able to provide written consent

Exclusion criteria

for Healthy Control Participants:

• Any acute or chronic pain condition (e.g., FM, arthritis)
• Current use of stimulant medications
• Routine use of substances of abuse
• Certain condition that interfere with Quantitative Sensory Testing (QST) and/or fMRI procedures (e.g., Peripheral neuropathy, implanted ferrous metal, claustrophobia etc) or/and any impairment, activity or situation that could prevent satisfactory completion of the study protocol