Neuro Imaging and Multimodal Alzheimer's Disease

Inclusion criteria

For all subjects :

• Capacities visual, auditory (authorized devices) and oral or written expression sufficient for the proper performance of tests
• Obtain informed written consent of the subject

Patients with AD :

• Outpatient accompanied by a "helping"
• No parenchymal lesions allowing isolation explain the symptoms on brain MRI (T1 and T2) carried more than 6 months prior to enrollment in the study. Patients with more than three hyperintense white matter or visible lacunar infarction or T2 FLAIR will not be included in the study.
• probable Alzheimer's disease diagnosis par with international standards
• Illness in a mild stage (CDR 1, 24 ≥ Mini-Mental State Examination (MMSE)> 18)
• activity of daily living (ADL) 4 items> 1/4

Patients with Alzheimer's disease at a pre-dementia stage:

• Alzheimer's Diagnosis pre-dementia based on the search criteria
• Illness in a mild stage (CDR 0.5, 30 ≥ MMSE ≥ 25)
• ADL items ≤ 4 1/4

Control subjects :

• 30 ≥ MMSE ≥ 27
• perfect autonomy in daily living (IADL = 0, CDR = 0)
• Neuropsychological evaluation not highlighting of impaired cognitive performance with focus on memory performance
• No parenchymal lesions on brain MRI.
• Lack of family history (first degree) of Alzheimer's disease

Exclusion criteria

• Subjects with a contra-indication to MRI (carrying a pacemaker or cardiac defibrillator, implanted a material activated by an electrical, magnetic or mechanical carriers hemostatic clips intracerebral aneurysms or carotid artery , holders of orthopedic implants, claustrophobia)
• Subjects with clinically significant gastrointestinal, renal, hepatic, endocrine, or cardiovascular
• Subjects with a psychiatric disorder or progressive neurological
• French Language level insufficient to be appropriately involved in neurophysiological evaluation
• less than 5 years Education (insufficient understanding level to participate in the study)
• Administrative problems: unable to give informed about information, not covered by a social security system
• Hypersensitivity to the active substance or to any of the excipients
• unbalanced diabetes mellitus
• Subjects treated by a non-steroidal anti-inflammatory