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Completed

NCT Number: NCT05669924

Neural Correlates of Acute Pain Dynamics

This work aims to study the neural correlates and determinants of pain dynamics related to changes in a noxious stimulus.

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Key information

Conditions

Pain Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Northwestern University

Chicago, Illinois, 60611, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-

Exclusion criteria

  • Pregnant
  • History of chronic pain
  • History of neurological diagnosis
  • History of psychiatric diagnosis

Treatment and study plan

Methylphenidate

Drug

0.35 mg/kg methylphenidate will be administered after baseline testing and 45 min-1 hr before post-intervention testing.

Placebo

Drug

Placebo for methylphenidate

Primary outcomes

  1. Effect of methylphenidate on acute pain dynamics

    Time frame: 6 months

    We will compare acute pain dynamics-i.e., the time series of pain visual analog scale ratings (0-100, where 0 = no pain and 100 = worst pain imaginable) obtained while delivering a changing noxious stimulus-during the methylphenidate condition to that of the placebo condition.

  2. Nucleus accumbens activation with acute pain dynamics

    Time frame: 6 months

    We will regress the time course of nucleus accumbens BOLD activity onto the latent time series obtained from our valence competition model. This will be supported by regressing the nucleus accumbens time course onto the pain VAS time course, allowing our findings to be compared to standard analyses in the literature.

Sponsors and collaborators

Lead sponsor

Northwestern University

Other

Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

Registry information

Official study title

The Neural Correlates of and Effects of Methylphenidate on Acute Pain Dynamics

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Jan 3, 2023
Registry last updated
May 1, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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