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NCT Number: NCT07521267

Nano Coated Orthodontic Miniscrews for en Mass Retraction of the Upper Arch

study will be directed to evaluate silver-hydroxyapatite nano-coated versus uncoated orthodontic miniscrews for en masse retraction of the upper anterior segment.

Recruiting

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Key information

Age range

14 year–20 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dental Medicine (Boys), Al-Azhar University

Cairo, Cairo Governorate, 4434103, Egypt

Location status: Recruiting

Location contact

Hashem Kh Al-Washali, MScCandidate

CONTACT

[email protected]

+01120042296

Hashem Kh Al-Washali, MScCandidate

PRINCIPAL_INVESTIGATOR

Mahmoud Fa Aboelmahasen, Phd

CONTACT

[email protected]

+01222993381

About this study

Silver-hydroxyapatite nanoparticles (Ag-HA NPs) have lately gained popularity in dentistry due to their unique combination of silver antibacterial activity and hydroxyapatite's osteoconductive, remineralizing characteristics. Ag-HA has shown potential in resolving two important clinical issues: infection control and anchoring stability. Coating orthodontic miniscrews with Ag-HA NPs has been demonstrated to reduce peri-implant biofilm growth by their antimicrobial effect, minimizing inflammation, and increasing osseointegration, thus increasing the long-term success of temporary anchoring devices (TADs).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Class I orthodontic cases with bimaxillary protrusion of the anterior segment of the upper jaw that need at least extraction for orthodontic treatment.
  • Age 14-20 years.
  • Good oral hygiene with healthy periodontium.
  • Need for an absolute skeletal anchorage.
  • Systemically healthy patients.

Exclusion criteria

  • Patient with craniofacial anomalies (e.g, cleft lip and palate)
  • Presence of systemic diseases or syndromes affecting bone metabolism (e.g, osteoporosis, rickets)
  • Poor oral hygiene or uncooperative patients.
  • Extensive dental caries or untreated periodontal disease.
  • History of trauma or surgery affecting the maxilla or mandible.

Treatment and study plan

Silver nanoparticles

Device

Patients will receive silver-hydroxyapatite nanocoated titanium miniscrews.These miniscrews will be placed in the maxillary bone for en masse retractonof the upper anterior teeth.

uncoated titanium miniscrews

Device

Patients will receive conventional uncoated titanium miniscrews of the same dimensions and design as the intervention of the group1, but without nano-coating.

Primary outcomes

  1. Assessment of the clinical and radiographically success rate of nanocoated versus uncoated orthodontic miniscrews after en masse retraction

    Time frame: about 6 months

    Assessment of the clinical and radiographically success rate of nanocoated versus uncoated orthodontic miniscrews after en masse retraction

Secondary outcomes

  1. Assessment of the rate of en masse retraction of the anterior segment of the upper arch

    Time frame: 6 months

    Assessment of the rate of en masse retraction of the anterior segment of the upper arch.

Study contacts

Contact information is provided by the study sponsor or research team.

Hashem Kh Al-Washali, MScCandidate

CONTACT

[email protected]

+01120042296

Mahmoud FA Aboelmahasen, Phd

CONTACT

[email protected]

+01222993318

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Evaluation of Silver-Hydroxyapatite Nano-coated Versus Uncoated Orthodontic Miniscrews for en Masse Retraction of the Upper Anterior Segment: A Randomized Clinical Trial

Important dates

Study start
2026
Primary completion
2028
Study completion
2029
First posted
Apr 9, 2026
Registry last updated
Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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