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NCT Number: NCT07466641

LLLLT vs Piezocision in Accelerating Orthodontic Canine Retraction

This comparative controlled clinical study aims to evaluate and compare the effectiveness of piezocision and low-level laser therapy (LLLT) as adjunctive interventions to accelerate orthodontic canine retraction. Participants will be randomly assigned to one of three groups: piezocision, LLLT, or a control group (no adjunctive procedure). The study will assess the impact of these interventions on the rate of tooth movement, the type of tooth movement, and patient experience.

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Key information

Conditions

Malocclusion, Angle Class II, Division 1 Bimaxillary Protrusion Class I Malocclusion Malocclusion Malocclusion, Angle Class I Malocclusion, Angle Class II Stomatognathic Diseases Tooth Diseases

Age range

18 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Outpatient Clinics of the Department of Orthodontics, Faculty of Dental Medicine, Boys, Cairo, Al-Azhar University.

Cairo, Cairo Governorate, Egypt

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age range 18-25 years.
  • Patients with crowding or protrusion requiring at least bilateral maxillary first premolar extraction followed by symmetrical canine retraction.
  • Full set of permanent dentition (third molar not considered).
  • Patients with good oral hygiene.

Exclusion criteria

  • Previous orthodontic treatment.
  • Patients taking medications or suffering from systemic conditions that can affect orthodontic tooth movement.
  • Active periodontal diseases and/or untreated carious lesions.
  • Congenital orofacial deformities.

Discontinuation criteria:

  • Multiple missing appointments.
  • Poor oral hygiene.
  • Multiple broken appliances to the extent that interferes with obtaining the treatment objectives.

Treatment and study plan

low level laser therapy

Procedure

On both right and left sides, LLLT will be performed at the beginning of canine retraction, after 3, 7, 14 days, and then every 14 days for a total four-month period.

Other names: LLLT

Piezocision

Procedure

On both right and left sides, a minimally invasive flapless piezocision procedure will be performed each month from the beginning of the canine retraction for a total four-month period.

Other names: Piezosurgery

Primary outcomes

  1. Rate of canine retraction

    Time frame: Four months from the beginning of maxillary canine retraction.

    The rate of distal movement of the maxillary canine measured in millimeters per month (mm/month).

Secondary outcomes

  1. Maxillary canine rotation and tipping.

    Time frame: Four months from the beginning of maxillary canine retraction.

    Measured in degrees

  2. Maxillary first molar mesial movement

    Time frame: Four months from the beginning of maxillary canine retraction.

    Maxillary first molar mesial movement (measured in mm)

  3. Maxillary first molar rotatiob

    Time frame: Four months from the beginning of maxillary canine retraction.

    (measured in degrees).

  4. Patient-Reported Pain Intensity

    Time frame: Four months from the beginning of maxillary canine retraction.

    Pain intensity will be measured using a 10-centimeter Visual Analogue Scale (VAS). The scale ranges from 0 to 10, where 0 represents "no pain" and 10 represents "the worst possible pain" . Therefore, higher scores indicate a worse outcome (greater pain intensity).

Study contacts

Contact information is provided by the study sponsor or research team.

Hesham N Al-Qamhawy

CONTACT

[email protected]

00201099767929

Sponsors and collaborators

Lead sponsor

Hesham Nabil Ali Al-Qamhawy

Other

Collaborators

  • Al-Azhar University

Registry information

Official study title

Effectiveness of Piezocision Versus Low-level Laser Therapy During Orthodontic Canine Retraction: A Comparative Controlled Clinical Study

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Mar 12, 2026
Registry last updated
May 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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