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NCT Number: NCT07717073

MyocarditIRM-Génétique - Genetic Sub-study of the French Cohort of Acute Myocarditis Cases Diagnosed by MRI

The aim of this retrospective, non-interventional study is to assess the prevalence and describe the genetic variants found in a cohort of patients with acute myocarditis confirmed by MRI. This is a study linked to the MyocarditIRM cohort, designed to collect genetic test results obtained as part of routine clinical care.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Acute Myocarditis Cardiomegaly Cardiomyopathies Cardiomyopathy, Dilated Cardiovascular Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Heart Diseases Laminopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Poitiers

Poitiers, France, 86000

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient enrolled in MyocarditIRM
  • Patient who has undergone genetic testing

Exclusion criteria

  • Patient who has objected to the reuse of their data

Treatment and study plan

Primary outcomes

  1. Prevalence and characterization of genetic variants (genes involved and ACMG classification) in patients with MRI-confirmed acute myocarditis.

    Time frame: From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)

Secondary outcomes

  1. All-cause mortality

    Time frame: From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)

    All-cause mortality during follow-up

  2. Cardiovascular mortality

    Time frame: From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)

    Cardiovascular mortality during follow-up

  3. Major adverse cardiovascular events

    Time frame: During index hospitalization and up to 10 years of follow-up (via SNDS linkage and medical records)

    Occurrence of major adverse cardiovascular events, including heart failure requiring hospitalization, newly diagnosed dilated cardiomyopathy not present prior to the myocarditis episode, ventricular arrhythmias, high-degree atrioventricular block, implantation of an implantable cardioverter-defibrillator (ICD), pacemaker, wearable cardioverter-defibrillator (life vest), or implantable loop recorder, recurrent myocarditis, and heart transplantation.

  4. Cardiac MRI sequelae

    Time frame: During follow-up imaging performed as part of routine clinical care, up to 10 years after index myocarditis episode

    Presence of myocardial sequelae on cardiac magnetic resonance imaging (MRI) during follow-up in patients who underwent follow-up imaging as part of routine clinical care

Sponsors and collaborators

Lead sponsor

French Cardiology Society

Other

Registry information

Acronym: MyocarditIRM-G

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Jul 21, 2026
Registry last updated
Jul 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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