Myocardial Bridging in Obstructive Hypertrophic Cardiomyopathy

This study investigated the impact of myocardial bridging (MB) and its characteristics on preoperative atrial fibrillation and survival in patients with obstructive hypertrophic cardiomyopathy (oHCM). We recruited 968 consecutive patients with oHCM who underwent myectomy at our institution between January 2015 and December 2019, including 144 patients with MB and 824 patients without MB. All patients received angiography before surgery. The diagnosis of preoperative atrial fibrillation was based on 12-lead electrocardiography, 24-hour Holter electrocardiography, or in-hospital electrocardiogram monitoring, which was extracted from patients' medical records. Surgical details and follow-up data were also collected.

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Key information

Conditions

Myocardial Bridging Aortic Stenosis, Subvalvular Aortic Valve Disease Aortic Valve Stenosis Arrhythmias, Cardiac Atrial Fibrillation Atrial Fibrillation (AF) Cardiomyopathies Cardiomyopathy, Hypertrophic Cardiovascular Abnormalities Cardiovascular Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Coronary Vessel Anomalies Heart Defects, Congenital Heart Diseases Heart Valve Diseases Obstructive Hypertrophic Cardiomyopathy Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fuwai Hospital

Beijing, Please Select, 475, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

I(i) age ≥ 18 years and (ii) diagnosis of oHCM based on clinical and echocardiographic evaluation.

Exclusion criteria

(i) a history of heart surgery (ii) Patients who had coronary atherosclerosis or myocardial infraction; (iii) Patients who had no angiography records.

Treatment and study plan

Coronary artery bypass grafting or unroofing

Procedure

Patients had an MB with >75% compression degree would receive coronary artery bypass grafting, and those who underwent unroofing may had a depth of MB < 5mm (whether deal with these MB with a depth <5mm depends on the surgeon and the period time of patients received a surgery).

Primary outcomes

All-cause death

Time frame: One month after discharge

Any death occurred one month after discharge

Secondary outcomes

New-onset AF

Time frame: One month after discharge.

Patients did not have AF before surgery, and AF occurred one month after discharge.
Composite endpoints

Time frame: One month after discharge

Composite endpoints including all-cause death, new-onset AF, and readmission due to heart failure, stroke, and other cardiovascular events (such as myocardial infarction, arrhythmia).

Sponsors and collaborators

Lead sponsor

Chinese Academy of Medical Sciences, Fuwai Hospital

Other

Registry information

Official study title

The Association Between Myocardial Bridging and Atrial Fibrillation in Patients With Obstructive Hypertrophic Cardiomyopathy

Acronym: MB in oHCM

Important dates

Study start: 2022
Primary completion: 2022
Study completion: 2022
First posted: Sep 19, 2024
Registry last updated: Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed