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OpenTrials
Completed

NCT Number: NCT04932889

Musculoskeletal Symptoms in Post Acute Covid-19 Patients

The patients whose musculoskeletal symptoms initiated or aggravated with Covid-19, were compared with the patients whose musculoskeletal symptoms did not change with Covid-19. The variables; the demographic and treatment datas, admission symptoms, post acute-Covid-19 symptoms, laboratory, chest computed tomography findings.

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Key information

About this study

There is a lack of an overview of the factors associated with post acute-Covid-19 musculoskeletal symptoms. The aims are;1-to evaluate the most frequent admission symptoms and the frequency of musculoskeletal symptoms in post acute-Covid-19 patients,2-to determine the related factors with the post acute-Covid-19 musculoskeletal symptoms.

In this retrospective study; the patients whose musculoskeletal symptoms initiated or aggravated with Covid-19, were compared wthe patients whose musculoskeletal symptoms did not change with Covid-19. The variables; the demographic and treatment datas, admission symptoms, post acute-Covid-19 symptoms, laboratory (complete blood count, C-reactive protein, ferritin, D-dimer), chest computed tomography findings.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being 18 years or older
  • Having Covid-19 treatment (home quarantine / hospital / intensive care unit) according to a positive polymerase chain reaction (PCR) test in a nasopharyngeal + oropharyngeal swab or chest CT.

Exclusion criteria

  • Patients who did not have musculoskeletal symptom records (admission symptoms and musculoskeletal symptoms such as; fatigue, spine / joint /muscle pain/ numbness) in patients files
  • Acute Covid-19 patients whose symptoms started less than 1 month

Treatment and study plan

Survey

Other

A detailed anamnesis was retrospectively recorded about age, gender, body mass index, education, working, the presence of any chronic disease (diabetes mellitus, hypertension, chronic obstructive pulmonary disease, cardiac disease, cancer, rheumatological disease…), smoking, duration of symptoms, usage of supplementing vitamins such as vitamin D,C, zinc…, treatment place (home quarantine, hospital, intensive care unit), duration of home quarantine and hospital treatment, the number of months since the onset of Covid-19 symptoms, usage of anticoagulants, treatment drugs such as hydroxychloroquine, favipiravir. Also the symptoms during the period of Covid-19 infection were recorded from patient files; cough, fever, dyspnea, chest pain, loss of smell and taste, sore throat, headache, no symptom, musculoskeletal symptoms such as: muscle, low back, back, joint pain.

Laboratory parameters

Other

The laboratory values of 182 patients, presence of chest computed tomography findings of 206 patients and symptoms of all patients during the period of Covid-19 infection, were retrospectively recorded. Laboratory values of hemoglobin, leucocyte, lymphocyte, platelet, C-reactive protein, erythrocyte sedimentation rate, ferritin, d-dimer, were recorded.

chest computed tomography

Other

Typical findings of chest CT were; bilateral, multifocal, peripheral ground glass opacities with/without consolidation, including the fissures, close to visceral pleural surfaces. Covid-19 Reporting and Data System (CO-RADS) was used for chest CT. CO-RADS assigns scores from 1 (very low suspicion of Covid-19) to 5 (very high suspicion of Covid-19).

Primary outcomes

  1. Rate of back pain

    Time frame: Baseline

    given as percentage %

  2. Chest computed tomography

    Time frame: Baseline

    Presence of covid-19 findings in chest computed tomography (covid findings positive or negative)

  3. Rate of low-back pain

    Time frame: Baseline

    given as percentage %

  4. Rate of fatigue

    Time frame: Baseline

    given as percentage %

  5. Rate of neck pain

    Time frame: Baseline

    given as percentage %

  6. Rate of dyspnea

    Time frame: baseline

    given as percentage %

  7. Rate of joint pain

    Time frame: Baseline

    given as percentage %

  8. Rate of chest pain

    Time frame: Baseline

    given as percentage %

  9. Rate of myalgia

    Time frame: Baseline

    given as percentage %

Secondary outcomes

  1. age

    Time frame: Baseline

    years

  2. Weight

    Time frame: Baseline

    kilograms

  3. gender

    Time frame: Baseline

    female or male

  4. Duration after the onset of covid-19

    Time frame: Baseline

    months

  5. Lymhocyte levels

    Time frame: Baseline

    10*3 cells/microliter

  6. D-dimer levels

    Time frame: Baseline

    miligram/Litre

  7. C-reactive protein

    Time frame: Baseline

    miligram/Litre

  8. Hemoglobin

    Time frame: Baseline

    gram/desilitre

  9. Platelet

    Time frame: Baseline

    10*3 cells/microliter

  10. Ferritin

    Time frame: Baseline

    nanogram/mililitre

Sponsors and collaborators

Lead sponsor

Eskisehir City Hospital

Other

Registry information

Official study title

Musculoskeletal Symptoms and Related Factors in Post Acute Covid-19 Patients

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Jun 21, 2021
Registry last updated
Jun 21, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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