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Completed

NCT Number: NCT04534374

Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed

This study investigated the effect of acute multiple joint, structural barbell resistance exercise on information processing speed and conflict-related neural activity in older adults via a crossover, sham control, randomized control trial.

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Key information

Conditions

Cognitive Decline Aging Behavior Cognition Disorders Cognitive Dysfunction Mental Disorders Motor Activity Neurocognitive Disorders

Age range

50 year–65 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan Normal University

Taipei, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male adults aged 50-65 years old
  • exercise ≥ 150 minutes/week
  • normal or corrected-to-normal vision
  • right-handed

Exclusion criteria

  • dementia (MMSE ≥ 24)
  • any medical condition listed on PARQ
  • depression (BDI-II score ≤ 13)
  • any diagnostic cardiovascular, neurological and other chronic diseases

Treatment and study plan

Resistance exercise

Behavioral

Barbell back squat, press, and deadlift for three sets of five repetitions with the weight closest to 75% of their estimated 1 repetition max. The participants were instructed to execute the movement with moderate speed (2s eccentric, 2s concentric, no pause in between). The rest period between sets and exercise movements was two to three minutes.

Stretching exercise (sham exercise)

Behavioral

Participants completed a passive stretching exercise session for a similar duration of time as the resistance exercise (≈ 30 min) as sham intervention, which included 15-20 stretching movements twice, holding each for 30 seconds as recommended by ACSM.

Primary outcomes

  1. Change of Information processing speed between resistance and stretching exercises

    Time frame: 5-30 minutes before and 10-35 minutes after each intervention.

    Choice reaction time of the Stroop test congruent condition. Unit: millisecond. Shorter reaction time means a better outcome.

  2. Change of Inhibitory control between resistance and stretching exercises

    Time frame: 5-30 minutes before and 10-35 minutes after each intervention.

    Interference score of the Stroop test. Unit: millisecond. Smaller interference score means a better outcome.

Secondary outcomes

  1. Change of Conflict-related neural activity between resistance and stretching exercises

    Time frame: 5-30 minutes before and 10-35 minutes after each intervention.

    N2b (event-related potential)

  2. Change of Neural activity related to locus coeruleus phasic response between resistance and stretching exercises

    Time frame: 5-30 minutes before and 10-35 minutes after each intervention.

    P3 (event-related potential)

Sponsors and collaborators

Lead sponsor

National Taiwan Normal University

Other

Registry information

Official study title

Acute Multiple Joint, Structural Barbell Resistance Exercise Improves Information Processing Speed and Decreases Conflict-related Neural Activity in Older Adults: A Crossover, Sham Control, Randomized Control Trial With REP

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Sep 1, 2020
Registry last updated
Sep 1, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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