Multiomics Profiling of CSF in Cardiac Arrest Survivors

The goal of this observational study is to identify further pathophysiologic mechanism of secondary brain injury following cardiac arrest by using serial multiomics profiling of serum and cerebrospinal fluid (CSF) samples. The main question it aims to answer is:

A. The main question it aims to answer is: What are the dynamic molecular changes in serum and CSF that reflect the pathophysiological mechanisms of secondary brain injury after cardiac arrest? B. What are the differences in serum and CSF multiomic signatures between varying severities of cardiac arrest, and how are these differences associated with the underlying pathophysiological mechanisms of secondary brain injury?

Serum and CSF samples that have already been prospectively collected from participants and stored in the BioBank will be used for this analysis.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Cardiac Arrest (CA) Brain Diseases Brain Ischemia Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Heart Arrest Heart Diseases Hypoxia Hypoxia, Brain Hypoxia-Ischemia, Brain Hypoxic-Ischemic Brain Injury Nervous System Diseases Pathological Conditions, Signs and Symptoms Post-Resuscitation Syndrome Signs and Symptoms Signs and Symptoms, Respiratory Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chungnam National University Hospital

Daejeon, 35015, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 18 years old
Out-of-hospital cardiac arrest (OHCA)
Patients who have received post-resuscitation care including temperature control due to unconsciousness (Glasgow Coma Score < 8) after sustained ROSC.
Patients who consented to the placement of lumbar catheter for storing cerebrospinal fluid and blood samples in a human biobank.

Exclusion criteria

Patients diagnosed with a central nervous system-related disease before cardiac arrest
Patients who have undergone extracorporeal circulatory membrane oxygenation therapy
Patients who died within 24 hours from post-resuscitation care

Treatment and study plan

Primary outcomes

Neurological outcome

Time frame: after 6 months from return of spontaneous circulation

Cerebral Performance Category (CPC) score

Secondary outcomes

The Pittsburgh Cardiac Arrest Category (PCAC)

Time frame: immediately after return of spontaneous circulation

Illness severity of cardiac arrest

Sponsors and collaborators

Lead sponsor

Chungnam National University Hospital

Other

Registry information

Official study title

Serial Multiomics Profiling Using Serum and Cerebrospinal Fluid Samples Following Out-of-hospital Cardiac Arrest: a Prospective Observational Study

Acronym: MOPCAS

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jul 29, 2025
Registry last updated: Jul 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting