Molecular Insights Into Post-Cardiac Arrest Brain Injury Via CSF Multi-Omics

The goal of this study is to uncover the molecular mechanisms responsible for secondary brain injury in patients with post-cardiac arrest syndrome by analyzing cerebrospinal fluid (CSF) using multi-omics techniques.

The main question this study aims to answer is:

Which genome-, transcriptome-, proteome-, and metabolome-level changes in CSF are associated with secondary brain injury after cardiac arrest?

To address this question, CSF samples collected from post-cardiac arrest patients will undergo multi-omics analyses. Identified molecular pathways will be used to screen existing drug databases and generate new therapeutic candidates through computational modeling and compound synthesis. These findings will provide the scientific foundation needed to design and implement future preclinical experiments using cardiac arrest animal models.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Cardiac Arrest (CA) Brain Diseases Brain Ischemia Cardiovascular Diseases Central Nervous System Diseases Cerebrospinal Fluid Cerebrovascular Disorders Heart Arrest Heart Diseases Hypoxia Hypoxia, Brain Hypoxia-Ischemia, Brain Hypoxic-Ischemic Brain Injury Multiomics Nervous System Diseases Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chungnam National University Hospital

Daejeon, Jung-gu, 35015, South Korea

Location status: Recruiting

Location contact

Jiyoung Choi

CONTACT

[email protected]

+82-42-280-6713

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients receiving post-resuscitation care after out-of-hospital cardiac arrest for secondary brain injury treatment.
Patients without contraindications for lumbar puncture catheter insertion for cerebrospinal fluid (CSF) collection. This includes the absence of:
Uncontrolled diabetes.Coagulation disorders.
Thrombocytopenia (platelet count $< 100,000).
A history of cirrhosis diagnosis.
Current receipt of low molecular weight heparin.
Current use of platelet inhibitors.
A history of posterior spinal fusion that may interfere with catheter insertion.
Local skin infection or rash at the puncture site.
Signs of systemic infection or sepsis.
A history of lumbar puncture within the past 6 hours.

Exclusion criteria

Cerebral Edema: Patients with evidence of cerebral edema on a brain computed tomography (CT) scan performed immediately after spontaneous circulation recovery.
Patients who underwent extracorporeal membrane oxygenation (ECMO).
Patients who could not maintain integrated therapy for more than 24 hours after cardiac arrest.
Patients with a history of acute or chronic brain disease.

Treatment and study plan

Primary outcomes

Neurological outcome

Time frame: at discharge (assessed up to 3 days), 3 months after return of spontaneous circulation (ROSC)

Neurological outcome assessed using the Cerebral Performance Category (CPC) scale (range 1-5; lower scores indicate better neurological function).

Study contacts

Contact information is provided by the study sponsor or research team.

Changshin Kang, MD. PhD

CONTACT

[email protected]

+821089928386

Sponsors and collaborators

Lead sponsor

Chungnam National University Hospital

Other

Registry information

Official study title

Identification of Novel Molecular Pathophysiological Mechanisms of Secondary Brain Injury in Post-cardiac Arrest Syndrome Patients Using Cerebrospinal Fluid Multi-omics Analysis

Acronym: PCABI-OMICS

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2028
First posted: Mar 18, 2026
Registry last updated: Mar 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting