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Completed

NCT Number: NCT00449631

Multidrug Resistance After Trabeculectomy With Mitomycin C

We investigate whether mitomycin C treatment during previous filtration surgery induces P-glycoprotein expression.

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Key information

Conditions

Glaucoma Eye Diseases Ocular Hypertension Trabeculectomy

Age range

8 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The University Hospital of Cologne

Cologne, 50924, Germany

About this study

Despite the adjuvant use of mitomycin C during trabeculectomy, short-term and long-term failures still occur. We investigate whether mitomycin C treatment during previous trabeculectomy induces P-glycoprotein expression. Expression of P-glycoprotein is analysed in surgically removed Tenon tissue using immunohistochemistry.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with planned trabeculectomy for elevated eye pressure
  • one third of patients without previous trabeculectomy
  • two thirds of patients with previous trabeculectomy (one third with and one third without the use of mitomycin C)

Exclusion criteria

  • patients not requiring surgery
  • patients with planned surgery for elevated eye pressure other than trabeculectomy

Sponsors and collaborators

Lead sponsor

University of Cologne

Other

Registry information

Important dates

First posted
Mar 20, 2007
Registry last updated
Mar 26, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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