The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy

The aim of the study is to investigate whether it is possible to predict the success of trabeculectomy in patients with glaucoma through the examination of mediators of wound healing in anterior chamber fluid. The success rate of trabeculectomy with mitomycin C in the literature is about 75%. This leads on the question why 25% of the patients received trabeculectomy are not sufficient treated and have not a long-term IOP reduction. Precisely this question is to be examined by the study.

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Key information

Conditions

Glaucoma Eye Diseases Ocular Hypertension Trabeculectomy Wound Healing

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Eye Hospital, University of Cologne

Cologne, North Rhine-Westphalia, 50937, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with glaucoma with a trabeculectomy required
60 eyes of 60 patients, The ratio of female / male is not involved.
Eye pressure under local therapy: 20mmHg and above (corrected with pachymetry table).
age of at least 18 years

Exclusion criteria

all patients not included in the group of inclusion criteria.
less than 50yl anterior chamber fluid could be collected during the operation.

Treatment and study plan

trabeculectomy

Procedure

Trabeculectomy with mitomycin C

Sponsors and collaborators

Lead sponsor

University of Cologne

Other

Registry information

Important dates

Study start: 2009
Primary completion: 2010
Study completion: 2012
First posted: May 4, 2010
Registry last updated: Nov 20, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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