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NCT Number: NCT01621659

Multidisciplinary Team IntervenTion in CArdio-ONcology (TITAN Study)

People with breast cancer often experience many short and long-term side effects as a result of both the cancer and the necessary treatments.

Receiving extra assessments and care from teams of multiple health professionals has been shown to be helpful for people with other health problems, such as heart disease. These 'multidisciplinary' teams may include nurses, doctors, pharmacists, dietitians, exercise therapists, counselors, and other specialists. Currently, the investigators do not know if receiving extra assessments from a multidisciplinary team is helpful for people receiving cancer treatment.

In this study, the investigators hope to learn the effect of extra assessments and early interventions from teams of health care professionals in people diagnosed with cancer, during and after the treatment period.

After initial assessments, participants will be randomized to multidisciplinary team intervention or usual care.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Breast Cancer Behavior Breast Diseases Breast Neoplasms Motor Activity Neoplasms Neoplasms by Site Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • histologically confirmed malignancy (breast or lymphoma);
  • scheduled to receive anthracycline and/or trastuzumab-based chemotherapy;
  • age ≥ 18 years;
  • willing to attend follow-up visits.

Exclusion criteria

  • physical disability preventing exercise testing or DEXA scan;
  • psychiatric disease or disorder precluding informed consent;
  • participation in other cardiotoxicity or exercise intervention study;
  • contraindication to anti-cancer therapy, including known heart failure, cardiomyopathy, or baseline LVEF < 50%;
  • previous anthracycline or trastuzumab-based therapy;
  • previous radiotherapy to thorax.

Treatment and study plan

Multidisciplinary team intervention

Behavioral

Intervention arm receives regular assessments and treatments from cardiology team, clinical nutrition, pharmacist, exercise physiologist and physiotherapist

Other names: cardiology assessment and intervention, nutritional assessment and intervention, exercise assessment and training, pharmacist assessment and counseling, physiotherapy assessment and training

Primary outcomes

  1. cardiac MRI

    Time frame: change from baseline to 12 months

    left ventricular ejection fraction (LVEF)

Secondary outcomes

  1. serum biomarkers

    Time frame: change from baseline to 12 months

    percent change in established biomarkers (troponin, BNP)

Other outcomes

  1. multidisciplinary team interventions

    Time frame: change from baseline to 12 months

    nutrition, exercise, physiotherapy interventions

Sponsors and collaborators

Lead sponsor

University of Alberta

Other

Registry information

Official study title

Multidisciplinary Team IntervenTion in CArdio-ONcology

Acronym: TITAN

Important dates

Study start
2014
Primary completion
2018
Study completion
2026
First posted
Jun 18, 2012
Registry last updated
May 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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