Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Postsurgical diagnosis of patients with primary solid tumors at high-risk of relapse as defined by one of the following:
° High-risk primary solid tumor (e.g., colorectal, ovarian, non-small cell lung cancer) (colorectal cancer only for Phase 1a)
- Stage 3 or
- ctDNA positive
° High-risk breast cancer
- Residual invasive disease in the breast or the lymph nodes following completion of neoadjuvant chemotherapy (NACT),
- Estrogen receptor (ER), and/or progesterone receptor (PR) positive and HER2 negative,
- CPS-EG score ≥ 3,
- CPS-EG score ≥2 w ith ypN+, or
- Recurrence score ≥ 25
- No evidence of disease
- Age ≥ 18
- Interval of ≥ 1 month but ≤ 2 years following completion of all definitive adjuvant therapy
- Non-exercising (i.e., < 30 minutes of moderate and < 20 mins of vigorous exercise/wk), as assessed by remote activity and heart rate tracking for a 7-day period prior to study entry)
° If ≥ 30 minutes but less than 45 minutes of moderate exercise/week, or if ≥ 20 minutes but less than 30 minutes of vigorous exercise/week, patients may be eligible, at the discretion of the PI.
- Cleared for exercise participation as per screening clearance via PAR-Q+
- Willingness to comply with all study-related procedures
Exclusion criteria
- Enrollment onto any other interventional investigational study except interventions determined by the PI not to confound study outcomes
- Any other current diagnosis of invasive cancer of any kind
- Distant metastatic malignancy of any kind
- Any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation
