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Completed

NCT Number: NCT02717559

Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): 10 Year Onsite Follow-up

In this study the investigators will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two and ten years post reconstruction surgery, aspects of the original injury and repair, and patient characteristics are risk factors for osteoarthritis after ACL reconstruction surgery.

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Key information

Conditions

Osteoarthritis Anterior Cruciate Ligament Injuries Arthritis Connective Tissue Diseases Joint Diseases Knee Injuries Leg Injuries Musculoskeletal Diseases Rheumatic Diseases Skin and Connective Tissue Diseases Wounds and Injuries

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Observational

About this study

The purpose of this study is to identify risk factors for signs and symptoms of osteoarthritis two and ten year post ACL reconstruction from information available at the time of surgery. Hypothesis: Smoking status, older age, higher BMI, increased severity of cartilage injuries, increased meniscal resection, revision surgery, and incidence of additional arthroscopic procedures will result in more symptoms and signs of osteoarthritis at 10-year follow-up.

Primary outcome measures will be the joint space width measured on weight-bearing radiographs, as well as the pain subscale of the Knee Injury and Osteoarthritis Score (KOOS).

Secondary outcome measures will include the knee related quality of life subscale of the Knee Injury and Osteoarthritis Score (KOOS).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Had primary unilateral ACL reconstruction performed by Dr. Kurt Spindler (Vanderbilt University), Dr. Christopher Kaeding (The Ohio State University), Dr. Rick Parker (Cleveland Clinic), Dr. Jack Andrish (Cleveland Clinic), Dr. Rick Wright (Washington University, St. Louis), or Dr. Matthew Matava (Washington University, St. Louis).
  • Participated in the 2 yr onsite visit

Exclusion criteria

  • Unable to be consented
  • Unable to participate for health reasons
  • History of intra-articular knee infection
  • History of total knee arthroplasty on either knee

Treatment and study plan

Primary outcomes

  1. Joint space width measured on weight-bearing radiographs

    Time frame: 10 years after ACL reconstruction surgery

  2. Pain subscale of the Knee Injury and Osteoarthritis Score (KOOS).

    Time frame: 10 years after ACL reconstruction surgery

Secondary outcomes

  1. Knee related quality of life subscale of the Knee Injury and Osteoarthritis Score (KOOS)

    Time frame: 10 years after ACL reconstruction surgery

Sponsors and collaborators

Lead sponsor

Vanderbilt University Medical Center

Other

Collaborators

  • Ohio State University
  • The Cleveland Clinic
  • Washington University School of Medicine

Registry information

Important dates

Study start
2016
Primary completion
2025
Study completion
2025
First posted
Mar 23, 2016
Registry last updated
Jan 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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