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NCT Number: NCT07649031

MRI as Noninvasive Innovative Approach in Detection and Monitoring of Malignant Oral Lesions in Fanconi Anemia Patients

This study being done to learn more about the use of medical Magnetic Resonance Imaging (mMRI) and dedicated dental MRI (ddMRI) as a non-invasive diagnosing tool when evaluating potential oral cancerous and precancerous lesions in Fanconi Anemia patients.

Recruiting

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Key information

Conditions

Fanconi Anemia Anemia Anemia, Aplastic Anemia, Hypoplastic, Congenital Bone Marrow Diseases Bone Marrow Failure Disorders Congenital Bone Marrow Failure Syndromes Congenital, Hereditary, and Neonatal Diseases and Abnormalities DNA Repair-Deficiency Disorders Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location status: Recruiting

Location contact

Carla Campbell, BS

CONTACT

[email protected]

612-625-6976

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with a diagnosis of Fanconi Anemia who are willing to participate and willing to have MRIs
  • Willing to provide informed consent

Exclusion criteria

  • Patient without diagnosis of FA
  • Patients with FA who are under the age of 18
  • Unable to tolerate any MRI due to claustrophobia
  • Any contraindication for the MRI
  • Unable to provide informed consent or comply with the study protocol

Treatment and study plan

MRIs

Diagnostic Test

mMRI and ddMRI

Primary outcomes

  1. sensitivity of mMRI and ddMRI in identifying dysplastic and malignant lesions in FA patients.

    Time frame: Immediately after MRI

    Proportion of positive lesions correctly diagnosed

  2. specificity of mMRI and ddMRI in identifying dysplastic and malignant lesions in FA patients.

    Time frame: Immediately after MRI

    Proportion of negative lesions correctly diagnosed

Study contacts

Contact information is provided by the study sponsor or research team.

Carla Campbell, BS

CONTACT

[email protected]

612-625-6976

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Registry information

Important dates

Study start
2026
Primary completion
2030
Study completion
2030
First posted
Jun 15, 2026
Registry last updated
Jul 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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