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NCT Number: NCT07134569

Motor Function Assessment and VR-based Motor Training in Adults With Autism Spectrum Disorder

The goal of this clinical trial is to learn if autism affect motor functions, including muscle strength, balance, and motor control? Additionally, understanding the motor functions, cognitive functions, and brain activation in individuals with autism, and verifying whether motor training can effectively improve muscle strength, balance, and motor control. The main questions aim to answer are:

[primary hypothesis or outcome measure 1]? [primary hypothesis or outcome measure 2]? If there is a comparison group: Researchers will compare [arm information] to see if [insert effects].

Participants will [describe the main tasks participants will be asked to do, interventions they'll be given and use bullets if it is more than 2 items].

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Key information

Conditions

Autism Autism Spectrum Disorder Autistic Disorder Child Development Disorders, Pervasive Mental Disorders Neurodevelopmental Disorders

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan University Hospital

Taipei, Taiwan

Location status: Recruiting

Location contact

Yi Ling Chien, Clinical Professor

CONTACT

[email protected]

+886 2312 3456 ext. 266013

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

> The ASD Group

Inclusion criteria

  • young adult aged between 18 and 45 years who had a diagnosis of ASD from a licensed mental health or medical professional based on DSM-5.
  • was motivated to complete the 6-week VR-based motor function training.
  • had a full-scale IQ > 70 on the WAIS-IV.

Exclusion criteria

  • a history of major mental illness (e.g., bipolar affective disorder, schizophrenia, or psychosis), neurological diseases (e.g., stroke, lumbar radiculopathy, or spinal cord injury) that hamper walking function, or neurosurgery.
  • visual impairment and/or hearing impairment that would preclude participation in motor assessment or training.
  • The Non-ASD control group

Inclusion criteria

  • young adult aged between 18 and 45 years who do not have a diagnosis of ASD.
  • had a full-scale IQ > 70 on the WAIS-IV.

Exclusion criteria

  • a history of major mental illness (e.g., bipolar affective disorder, schizophrenia, or psychosis), neurological diseases (e.g., stroke, lumbar radiculopathy, or spinal cord injury), or neurosurgery that hamper walking function.
  • visual impairment and/or hearing impairment that would preclude participation in motor assessment or training.

Treatment and study plan

VR-based motor training

Behavioral

Six weeks, twice per week.

Primary outcomes

  1. The performance of movement operational assessment

    Time frame: 40 minutes

    Participants will take movement operational assessment, which composed of different tests, such as Timed Up and Go Test (TUG), the 10-meter walk test (10MWT) and the 6-minute walk test (6WMT)

  2. The performance of motor coordination control

    Time frame: 1 hour, twice

    the performance recorded with Vicon, an motion capture system, and Single Leg Stance Test

Secondary outcomes

  1. The N-back Task performance

    Time frame: 40 minutes

  2. The performance of Timed Up and Go Test (TUG)

    Time frame: 1 minute, twice

  3. The performance of the 10-meter walk test (10MWT)

    Time frame: 1 minute, twice

  4. The performance of 6-minute walk test (6WMT)

    Time frame: 6 minutes, twice

Study contacts

Contact information is provided by the study sponsor or research team.

Yi Ling Chien, Clinical Professor

CONTACT

[email protected]

+886 2-23123456 ext. 266013

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Aug 21, 2025
Registry last updated
Jan 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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