Skip to main content
OpenTrials
Completed

NCT Number: NCT03190681

Motivation and Methylphenidate

The purpose of this study is to evaluate the impact of methylphenidate, a mixed dopaminergic and noradrenergic agent, onto the different components of motivation: decision-making, effort allocation and instrumental learning.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Motivation Apathy Behavior Impulsive Behavior Lethargy Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Centre d'investigation clinique, Institut du Cerveau et de la Moelle

Paris, 75013, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • weight>= 50kg and <=90kg
  • free and informed consent
  • social security affiliation
  • no chronic illness
  • no previous participation to a protocol wth similar tasks
  • no special legal status (guardianship,trusteeship)
  • no personnal or familial neurologic or psychiatric background
  • no contraceptive device for a reproductive woman

Exclusion criteria

  • inability to squeeze a handgrip
  • smoking
  • psychoactive substance consumption less than 3 weeks ago
  • pregnant or breastfeeding woman
  • hypersensitivity to methylphenidate
  • hyperthyroidism
  • cardiovascular or cerebrovascular disease
  • respiratory, hepatic or renal failure
  • glaucoma
  • pheochromocytoma
  • gluten intolerance or hypersensitivity
  • galactosemia, glucose malabsorption syndrome, lactase deficit
  • countraindicated meds (IMAO, IMAO-A, orhtosympathomimetics, alcaloids, linezolin, enzymatic inducers, psycho-active drugs)

Treatment and study plan

Ritalin (methylphenidate)10Mg Tablet

Drug

oral ingestion of 3 tablets in a single-dose

Placebo oral tablet

Drug

oral ingestion of 3 tablets in a single-dose

Primary outcomes

  1. coefficient of sensitivity to reward

    Time frame: two hours after administration

    Parameter characterizing the influence of reward expectation/experience onto behavior for each individual.

    This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task).

Secondary outcomes

  1. coefficient of sensitivity to effort

    Time frame: two hours after administration

    Parameter characterizing the influence of effort expectation/experience onto behavior for each individual.

    This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task).

  2. coefficient of sensitivity to punishment

    Time frame: two hours after administration

    Parameter characterizing the influence of punishment expectation/experience onto behavior for each individual.

    This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task).

  3. coefficient of sensitivity to delay

    Time frame: two hours after administration

    Parameter characterizing the influence of delay expectation onto behavior for each individual.

    This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task).

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Registry information

Official study title

Etude Comparative Monocentrique, randomisée, en Cross-over, en Double Aveugle, Contre Placebo, de l'Action du méthylphénidate Sur Les paramètres Cognitifs de la Motivation

Acronym: MBB_MPH

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Jun 19, 2017
Registry last updated
Apr 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.