Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT07067632

Mortality Outcome of Controlled Blood Pressure Participants

Despite advances in antihypertensive therapy, some patients with well-controlled blood pressure still experience fatal outcomes. This paradox raises critical questions about the efficacy of blood pressure-targeted interventions and whether BP control alone ensures survival. This systematic review and meta-analysis aims to evaluate all-cause mortality and cardiovascular death among hypertensive patients who achieved BP targets in RCTs or open-label trials.

To determine whether achieving controlled blood pressure through intentional intervention (pharmacological or procedural) in RCTs or open-label studies reduces mortality (all-cause and cardiovascular) in hypertensive patients.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Notify Me

Key information

Conditions

Valid MeSH Conditions Cardiovascular Diseases Hypertension Hypertension (HTN) Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Nathaphong

Bangkok, 10110, Thailand

About this study

Sensitivity Analyses Excluding high-risk of bias studies Excluding short follow-up (<1 year)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults ≥18 years with diagnosed hypertension

Blood pressure controlled at target values defined by the study (e.g., <140/90 mmHg or <130/80 mmHg)

Any comorbidity allowed unless the study focuses on pregnancy or pediatric population

Exclusion criteria

  • Observational or retrospective studies

Pediatric or pregnant participants

Case reports, editorials, or conference abstracts without full data

Studies not reporting mortality outcomes separately for controlled BP

Treatment and study plan

Antihypertensive treatment

Drug

Any intervention (pharmacological, device-based, lifestyle) intentionally directed at lowering BP

Control groups receiving placebo, standard of care, or no intervention

Other names: device-based blood pressure lowering, lifestyle modification

Primary outcomes

  1. All-cause mortality

    Time frame: 100 year

    All cause mortality by controlable hypertension treatment

Sponsors and collaborators

Lead sponsor

DejthidaNathaphong

Other

Registry information

Official study title

Mortality Outcome of Controlled Hypertension in Randomized Controlled or Open-label Study Intentionally Directed Intervention Effect Blood Pressure: A Systematic Review and Meta-Analysis

Acronym: HTN-Mort

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Jul 16, 2025
Registry last updated
Jul 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.