Morphometric Analysis of Orbital Structures in Graves´ Orbitopathy

The purpose of this protocol is to study orbital structures in Graves´ Disease using multidetector computed tomography and color doppler imaging.

Some changes in orbital structures detected by imaging exams could predict severity of the ocular Graves´disease. Thus the study could be useful in improve medical management of patients with Graves´ Disease.

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Key information

Conditions

Dysthyroid Orbitopathy Autoimmune Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Endocrine System Diseases Exophthalmos Eye Diseases Eye Diseases, Hereditary Genetic Diseases, Inborn Goiter Graves Disease Graves Ophthalmopathy Hyperthyroidism Immune System Diseases Orbital Diseases Thyroid Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

General Hospital - University of Sao Paulo - School of Medicine

São Paulo, 05409 000, Brazil

About this study

Morphometric analysis of orbital structures in Graves´ Orbitopathy using multidetector computed tomography scan and color doppler imaging:

Patients with Graves´ orbitopathy are evaluated by a complete ophthalmic examination.A prospective study with Multidetector CT scan and Color Doppler of these patients are made to develop parameters capable to predict Dysthyroid Optic Neuropathy (DON).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Graves´Orbitopathy diagnosed based on previously reported criteria
Age above 20 years
Good cooperation for performing Visual Field test
Spherical refraction within ± 5 D and cylinder correction within ± 3 D

Exclusion criteria

Graves´Orbitopathy not diagnosed

Treatment and study plan

Primary outcomes

screening indexes for dysthyroid optic neuropathy

Time frame: indexes above 60% of orbital apex crowding were high suspected for DON

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Registry information

Official study title

Morphometric Analysis of Orbital Structures in Graves´ Orbitopathy Using Multidetector Computed Tomography Scan and Color Doppler Imaging.

Important dates

Study start: 2005
Primary completion: 2013
Study completion: 2013
First posted: Apr 24, 2008
Registry last updated: Nov 19, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed