Momordica Charantia and Dihydroartemisinin-piperaquined-primaquine for Uncomplicated Plasmodium Falciparum Malaria Patients in Southwest Sumba Regency

The Study was conducted in Kori Primary Health Cender, Sumba Barat Daya District, East Nusa Tenggara Province on Sumba Island.

The study subject received either 3 day of dihydroartemisinin-piperaquine and primaquine 1 day on first day (DHP+PQ) or extract of bitter melon (Momordica charantia/MC) + Placebo 1 day on first day according to their body weight.

Patients with fever or history of fever within the past 24 hours were screened by microscopic examination of giemsa stained tihick blood films to detect Plasmodium falciparum infection.

All Patient were allocated by single blind randomization to receive DHP (on day 0 to day 2)+PQ (on day 0 only) or extract of bitter melon (Momordica charantia/MC) (on day 0 to day 2)+placebo (on day 0 only). The procedures of drug administration in the study were as follows:

Inclusion criteria

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• Age ≥ 18 years old male or female up to 60 years old
• Single Plasmodium falciparum infection based on microscopic examination.
• Count the parasites for Plasmodium falciparum at least 2 large visual field asexual parasites (LPB) by examining 15 LPB
• Density of parasites 1000-100,000/micro liter
• Has no history of uncontrolled comorbidities
• History of fever in the last 24 hours for falciparum malaria
• Not taking other antimalarial drugs in the last 2 weeks.
• Have no previous history of malaria.
• Willing to come to the health facility according to the specified follow-up schedule.
• Willing to participate in research and established procedures.
• There is no history of allergy to antimalarial drugs.

Exclusion criteria

• Signs of general weakness, or decreased consciousness or recurrent seizures or circulation failure or pulmonary edema or signs of anemia or yellow body and slightly red urine.
• If the examination results show mixed Plasmodium and non-Plasmodium falciparum.
• Has a history of severe liver, kidney and heart dysfunction, bradycardia and heart rhythm disturbances.
• Does not control regularly according to the research schedule
• Pregnant and lactating women
• There are signs of severe malaria
• Patients with chronic diseases, for example: heart, kidney, liver, HIV.
• Mixed infection.