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Recruiting

NCT Number: NCT05852522

Molecularly Aided Stratification for Tumor Eradication Research

NCT/DKFZ/DKTK MASTER is a prospective, continuously recruiting, multicenter observational study for biology-guided stratification of adults with rare cancers, including rare subtypes of common entities, using comprehensive molecular profiling, and clinical decision-making in a multidisciplinary molecular tumor board.

Recruiting

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Key information

Conditions

Rare Cancers Multiomics

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

German Cancer Research Center

Heidelberg, 69120, Germany

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Rare cancer (Incidence <6/100,000 persons/year) or Rare subtype of a more common entity (case-by-case decision; example: pancreatic ductal adenocarcinoma without KRAS mutation)

Metastatic and/or locally advanced cancer with no curative therapy option and indication for systemic therapy

Exclusion criteria

Severe neurological or psychiatric disorder interfering with the ability to give oral and written informed consent

Treatment and study plan

Primary outcomes

  1. progression free survival

    Time frame: 5 years

    Time period of progression survival from date of multiomics analysis

  2. overall survival

    Time frame: 10 years

    time period of survival from date of diagnosis

Secondary outcomes

  1. response to antitumor treatment

    Time frame: 5 months

    response according to RECIST v.1.1 criteria to antitumor treatment applied after multiomics analysis

Study contacts

Contact information is provided by the study sponsor or research team.

Richard F Schlenk, M.D.

CONTACT

[email protected]

+49 6221 ext. 560

Sponsors and collaborators

Lead sponsor

German Cancer Research Center

Other

Collaborators

  • German Consortium for Translational Cancer Research

Registry information

Official study title

NCT MASTER Plattform Molecularly Aided Stratification for Tumor Eradication Research

Acronym: NCT-MASTER

Important dates

Study start
2018
Primary completion
2028
Study completion
2029
First posted
May 10, 2023
Registry last updated
Mar 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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