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NCT Number: NCT07270965

Moisturization and Skin Hydration Study

Skin moisturization is important for patients with atopic dermatitis, commonly known as eczema. Moisturizing right after bathing is widely accepted as the best method to keep skin hydrated. However, there is conflicting research on the timing of moisturizing. The goal of this clinical study is to evaluate the preference of moisturizing while showering/bathing compared to after towel drying in adolescents aged 12-18 with eczema. The main question it aims to answer are:

* Which moisturization technique is preferred: while showering/bathing or after towel drying? * How do these techniques affect investigator-assessed eczema severity, patient-reported itch scores, and objective skin hydration measurements?

Researchers will compare applying moisturizer while in the shower/bath to after towel drying and to which technique is preferred among participants and if there are different effects on eczema and skin hydration.

Participants will:

* Apply moisturizer while showering/bathing for one month and after towel drying for one month. * Complete questionnaires on moisturization technique, skin feel, and itchiness. * Undergo skin hydration measurements using a Corneometer® CM825 device.

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Key information

Conditions

Atopic Dermatitis (AD) Atopic Dermatitis (Eczema) Congenital, Hereditary, and Neonatal Diseases and Abnormalities Dermatitis Dermatitis, Atopic Eczema Genetic Diseases, Inborn Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Skin Diseases Skin Diseases, Eczematous Skin Diseases, Genetic Skin and Connective Tissue Diseases

Age range

12 year–18 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

BC Children's Hospital

Vancouver, British Columbia, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants must have a diagnosis of atopic dermatitis/eczema.
  • Participants must be between the age of 12-18.
  • Participants must be able to bathe independently.
  • Participants will be English speaking and able to complete questionnaires.

Exclusion criteria

  • Participants who use topical corticosteroids between one inch above the wrist and 1 inch below the elbow from 1 month on both arms prior to the study until the final visit.
  • Participants who have a known allergy to the moisturizer cream (Cerave Moisturizing Cream) provided.

Treatment and study plan

Moisturizing while in shower/bath

Behavioral

Applying moisturizer in the shower/bath.

Moisturizing after towel drying

Behavioral

Applying moisturizer out of the shower/bath after towel drying.

Primary outcomes

  1. Proportion of Participants Preferring Each Moisturization Technique

    Time frame: Through study completion, an average of 2 months.

    Participant reported preference of moisturization technique

Secondary outcomes

  1. Skin Hydration Level

    Time frame: Through study completion, an average of 2 months.

    Skin electrical capacitance measured using Corneometer® CM825 as an indicator of skin hydration.

Other outcomes

  1. Eczema Severity Score

    Time frame: Through study completion, an average of 2 months.

    Eczema severity will be assessed by clinicians using the Validated Investigator Global Assessment Scale for Atopic Dermatitis (vIGA-AD™). Scores range from 1 to 4, with higher scores indicating more severe eczema/atopic dermatitis (worse outcome).

  2. Itch Intensity

    Time frame: Through study completion, an average of 2 months.

    Itch intensity will be assessed using a patient-reported Numeric Rating Scale (NRS) ranging from 1 to 10, where higher scores indicate greater itch severity (worse outcome). Participants will report both average itch and worst itch experienced within the past 24 hours.

Study contacts

Contact information is provided by the study sponsor or research team.

Wingfield Rehmus, MD, MPH

CONTACT

[email protected]

1-604-875-2606

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Collaborators

  • L'Oreal

Registry information

Official study title

Understanding the Effect of Pre-Drying Moisturization on Skin Hydration

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 8, 2025
Registry last updated
Dec 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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