Modifiable Risk Factors for Cognitive Dysfunction in Patients With Coronary Heart Disease

This prospective observational study aims to investigate the association between risk factors and cognitive function in patients with coronary heart disease (CHD), and to explore the underlying mechanisms involving metabolic parameters and multimodal imaging features. A total of 2,352 participants will be enrolled from Beijing Anzhen Hospital, Capital Medical University, China. Eligible participants are adults (≥18 years) with confirmed CHD who undergo systematic neuropsychological assessment during hospitalization. Comprehensive assessments include cognitive function tests (MMSE, MoCA, BCAT, AD8), metabolic evaluations (fasting glucose, insulin, HbA1c, ceramides), coronary computed tomography angiography (CCTA), cardiac magnetic resonance (CMR), sleep respiratory monitoring, and frailty and psychological assessments.The primary outcome is cognitive impairment. The study will identify potential risk factors and provide insights into early identification and personalized intervention strategies for cognitive decline in CHD patients.This study is led by the National Clinical Research Center for Cardiovascular Diseases and invited to be carried out by several Chinese centers including Beijing Anzhen Hospital.

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Key information

Conditions

Coronary Heart Disease Cardiovascular Diseases Cognition Disorders Cognitive Dysfunction Cognitive Impairment, Mild Coronary Disease Heart Diseases Mental Disorders Myocardial Ischemia Neurocognitive Disorders Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Beijing Anzhen Hospital

Beijing, China

Location status: Recruiting

Location contact

Chenchen Tu, Chief Physician

CONTACT

[email protected]

15201648899

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 18 years
Diagnosis of coronary heart disease (meeting at least one of the following):

Coronary angiography or coronary CTA showing ≥50% stenosis in ≥1 major coronary artery;
Established diagnosis of coronary heart disease with prior medical, interventional, or surgical treatment;
Objective evidence of myocardial ischemia or typical clinical symptoms
Completion of standardized neuropsychological assessment during hospitalization
Completion of metabolic marker evaluation (fasting glucose, insulin, HbA1c, etc.) and agreement to undergo relevant imaging and functional assessments
Provision of signed written informed consent

Exclusion criteria

Previously diagnosed dementia.
History of stroke, cerebral hemorrhage, or other central nervous system diseases known to cause cognitive impairment.
Severe psychiatric disorders (e.g., schizophrenia, bipolar disorder).
Pregnancy or breastfeeding.

Treatment and study plan

Primary outcomes

Cognitive impairment

Time frame: 2026-2031

Cognitive impairment in patients with coronary heart disease, defined by standardized neuropsychological assessments including the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Brief Cognitive Assessment Tool (BCAT), and Alzheimer's Disease 8-Item Screening Questionnaire (AD8), evaluated as a binary outcome (presence or absence of cognitive impairment).

Study contacts

Contact information is provided by the study sponsor or research team.

Chenchen Tu, Chief Physician

CONTACT

[email protected]

15201648899

Sponsors and collaborators

Lead sponsor

Beijing Anzhen Hospital

Other

Registry information

Official study title

Association Between Modifiable Risk Factors and Cognitive Function in Patients With Coronary Heart Disease

Important dates

Study start: 2025
Primary completion: 2031
Study completion: 2031
First posted: Jun 18, 2026
Registry last updated: Jul 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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