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Completed

NCT Number: NCT01183052

Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients

The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.

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Key information

Conditions

COPD Patients Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

50 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clinique du Souffle La Vallonie, Lodève, France

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About this study

Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Sedentary mild to severe COPD patients

Exclusion criteria

  • Neuromuscular disease
  • Chronic heart failure
  • Renal diseases
  • Liver diseases
  • Obesity

Treatment and study plan

Training

Other

20 sessions of training

Other names: CT

Primary outcomes

  1. Cellular effects of exercise training at the ventilatory threshold intensity

    Time frame: 6 to 8 weeks

Sponsors and collaborators

Lead sponsor

5 Santé

Other

Collaborators

  • Centre Hospitalier Régional Universitaire Montpellier
  • Institut National de la Santé Et de la Recherche Médicale, France

Registry information

Official study title

Mitochondrial Respiratory Chain and Peripheral Muscle Dysfunction in COPD Patients

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Aug 17, 2010
Registry last updated
Sep 5, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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