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OpenTrials
Completed

NCT Number: NCT01475812

Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients

Introduction: Chronic obstructive pulmonary disease is a condition characterized by airflow limitation usually progressive and associated with inflammatory response of lung noxious particles. During a physical activity chronic obstructive pulmonary disease patients may develop dynamic pulmonary hyperinflation, increased dyspnea perception and decreased activity performance. The investigators hypothesize that some specific activities of daily living induce dynamic pulmonary hyperinflation in COPD patients. Objective: To measure dynamic lung hyperinflation and its influence in dyspnea perception in moderate and severe chronic obstructive pulmonary disease patients after activities of daily living. Methods: The investigators measured inspiratory capacity, dyspnea sensation, peripheral oxygen saturation, heart rate and respiratory rate in 19 chronic obstructive pulmonary disease (COPD) patients. These measurements were taken at rest and after daily living activities (such as going up and down a set of stairs, going up and down a ramp and sweeping and mopping a room).

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Key information

Conditions

Dynamic Lung Hyperinflation Activities of Daily Livin. Behavior COPD Patients Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Motor Activity Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Federal University of São Paulo

São Paulo, São Paulo/SP, 05414000, Brazil

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • COPD patients diagnosed with moderate to very severe airway obstruction according to GOLD classification (9)
  • clinical stability with no clinical exacerbation during the previous 30 days prior to the beginning of the study and to sign an informed consent form

Exclusion criteria

  • Inability to perform the slow vital capacity maneuver
  • excessive perceived dyspnea during the test
  • arterial oxyhemoglobin saturation (SpO2) lower than 80% during activities and/or need of oxygen supplementation

Treatment and study plan

Hyperinflation and ADL

Other

Assessment of dynamic pulmonary hyperinflation during activities of daily living in COPD patients.

Primary outcomes

  1. Inspiratory capacity variability within the accomplishment of activities of daily living in COPD patients.

    Time frame: 3 months

Sponsors and collaborators

Lead sponsor

Federal University of São Paulo

Other

Registry information

Acronym: Hyperinflation

Important dates

Study start
2007
First posted
Nov 21, 2011
Registry last updated
Nov 21, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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