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OpenTrials
Completed

NCT Number: NCT00784797

Misopristol Versus Pitocin for Second Trimester Abortion

Second trimester abortion can be done surgically or medically. Medical abortion with mifepristone and misopristol is one of the common protocol, but misopristol have high rate side effect. The investigators recent study proved the efficacy of pitocin after mifepristone in second trimester abortion with minimal side effects.

Working hypothesis and aims: To compare misopristol and pitocin after mifepristone preparation in second trimester in seccess rate, interval to abortion, side effects and patient satisfaction.

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Key information

Conditions

Abortion, Missed Abortion, Spontaneous Female Urogenital Diseases and Pregnancy Complications Pregnancy Complications Urogenital Diseases

Age range

18 year–50 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Hadassah Medical Organization

Jerusalem, Israel

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • midtrimester late abortion
  • midtrimester induced abortion

Exclusion criteria

  • placenta previa
  • infected abortion
  • rupture of membranes
  • s/p cesarean section *2 or more

Treatment and study plan

mifepristone and misopristol

Drug

200 mg mifepristone and after 48 hours vaginal misopristol 800 mgr followed by oral misopristol 400 mgr every 3 hours for maxamum 5 doses

mifepristone and oxytocin

Drug

200 mg mifepristone followed 48 hours with high dose oxytocin drip (9 unit per hour)

Primary outcomes

  1. Success rate of abortion

    Time frame: 24 hours

  2. Interval to abortion

    Time frame: 24 hours

Secondary outcomes

  1. Side effects

    Time frame: 24 hours

Sponsors and collaborators

Lead sponsor

Hadassah Medical Organization

Other

Registry information

Official study title

Comparison Between Misopristol and Pitocin After Mifepristone Preparation for Second Trimeter Abortion

Important dates

Study start
2009
Primary completion
2012
Study completion
2012
First posted
Nov 4, 2008
Registry last updated
Nov 21, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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