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Completed

NCT Number: NCT01905267

Mindfulness Intervention to Study the Neurobiology of Depression

The Pediatric Mood Disorders Program at the University of Illinois at Chicago is conducting a research study examining how mindfulness can help teenagers stay healthy and prevent depression relapse.

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Key information

Conditions

Depression Behavior Behavioral Symptoms

Age range

12 year–18 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Illinois at Chicago Pediatric Mood Disorders Program

Chicago, Illinois, 60608, United States

About this study

Study involves:

  • Brain scan using fMRI technology
  • Questions about mood and behavior
  • Meeting with a clinician
  • Possibility of 8 weekly treatment sessions using mindfulness
  • Ongoing assessment of depression for next 2 years

Eligible participants will be compensated for their time.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • between the ages of 12 and 18
  • history of major depressive disorder

Exclusion criteria

  • braces
  • afraid of small spaces

Treatment and study plan

Rumination-Focused Cognitive Behavior Therapy

Behavioral

This intervention targets rumination and other maladaptive forms of emotion regulation such as suppression and avoidance and provides skills training in effective coping strategies. Mindfulness is a key component of this intervention as a strategy for disengaging from one's thoughts. Strategies from Dialectical Behavior Therapy (DBT), such as the use of effective interpersonal skills, are also included as methods for regulating strong emotion. Rumination-Focused Cognitive Behavior Therapy is a structured, manual based program designed to be delivered weekly over eight weeks. Sessions are 60-90 minutes in length.

Primary outcomes

  1. Change in Children's Depression Rating Scale - Revised

    Time frame: Baseline, 8 week

    clinician measure completed with adolescent and parent Total scores reported. Range is between 17-119 Higher scores mean higher depressive symptoms

Secondary outcomes

  1. Change in Reynolds Adolescent Depression Scale

    Time frame: Baseline, 8 week

    Self report adolescent depression total score. Range is 30-120 with higher scores meaning greater depressive symptoms.

Sponsors and collaborators

Lead sponsor

University of Illinois at Chicago

Other

Registry information

Acronym: MIND

Important dates

Study start
2013
Primary completion
2017
Study completion
2017
First posted
Jul 23, 2013
Registry last updated
Jul 30, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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