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NCT Number: NCT07266597

Micropulse Laser Photocoagulation in Diabetic Macular Edema

To assess the safety and efficacy of 532 nm subthreshold micropulse laser 5 % duty cycle compared with 15 % duty cycle in treatment of diabetic macular edema .

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

prospective interventional randomized comparative study that will be conducted on Patients with diabetic retinopathy who Are More than 18 years old with diabetic macular edema with a central retinal thickness < 400 um and best corrected visual acuity between 6/18 and 6/60 .

The participants will be divided randomly into two groups All Patients will receive single session of 532 nm subthreshold micropulse laser ,the following parameters will be used in all cases as follows,spot size : 200-µm ,exposure duration:200-ms ,power : 500-mW

While duty cycle will differ between 2 groups as follows :- Group A : will be treated using 5 % duty cycle . Group B : will be treated using 15 % duty cycle . follow up visits as follows 1 week ,4 weeks 12 weeks after laser therapy .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with diabetic retinopathy who:

  • Are More than 18 years old .
  • have diabetic macular edema with a central retinal thickness < 400 um .
  • have best corrected visual acuity between 6/18 and 6/60 .

Exclusion criteria

  • Previous lasered retina , Anti - VEGF injection or vitrectomy .
  • Extensive Macular ischemia on FFA .
  • Media opacity .
  • Associated ocular pathology as glaucoma, CNV (choroidal neovascularization ) , AMD (age related macular degenerations ), epiretinal membrane vitreomacular traction and retinal vein occlusion .

Treatment and study plan

micropulse laser photocoagulation

Procedure

micropulse laser photocoagulation in treatment of diabetic macular edema, 5% duty cycle

Primary outcomes

  1. central macular thickness

    Time frame: 3 months

    assessment of change of central macular thickness before and after laser treatment

Study contacts

Contact information is provided by the study sponsor or research team.

mortada ahmed abu zeid, professor

CONTACT

01203324446

younis shabaan abu alhassan, resident

CONTACT

[email protected]

01027389944

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Micropulse Laser Photocoagulation Treatment of Diabetic Macular Edema ; 5 % Versus 15 % Duty Cycle

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Dec 5, 2025
Registry last updated
Dec 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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