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NCT Number: NCT07001644

Microneedling Versus Carboxytherapy in Stria Distensae Rubra

The aim of this study is to evaluate and compare the efficacy and safety of microneedling and carboxytherapy either with or without platelet-rich plasma in the treatment of striae distensae rubra.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Striae Distensae Pathological Conditions, Signs and Symptoms Signs and Symptoms Skin Manifestations

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Alexandria Faculty of Medicine

Alexandria, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female patients.
  • Age ranging from 18-45 years old.
  • Fitzpatrick skin type III-IV.
  • Striae distensae rubra on the abdomen (bilateral and more or less symmetrical).

Exclusion criteria

  • Patients taking immunosuppressants or having any disease affecting wound healing including diabetes.
  • Patients receiving systemic glucocorticoids for chronic health conditions.
  • Patients with chronic dermatologic diseases such as psoriasis and vitiligo.
  • Pregnant and lactating females.
  • Patients with a tendency for keloid formation.
  • Patients with endocrine disturbance.
  • Patients with autoimmune diseases, systemic diseases such as severe anemia, respiratory, cardiac, renal or liver disorder.
  • Patients with bleeding and coagulation disorders.
  • Patients who received any form of treatment for their SD in the past 6 months.

Treatment and study plan

microneedling

Device

microneedling with topical application of PRP on one side of abdomen and microneedling only on the other side.

Carboxytherapy

Device

carboxytherapy with intradermal injection of PRP on one side of abdomen and carboxytherapy only on the other side.

Primary outcomes

  1. Reduction in the size of the stria distensae rubra

    Time frame: group I: six sessions over 18 weeks , group II: 6 sessions over 12 weeks, followed in both groups by three months of follow up

    will be assessed by digital photography, actual measurement of the stria before and after treatment, and objective assessment of the percent of improvement

Sponsors and collaborators

Lead sponsor

Alexandria University

Other

Registry information

Official study title

Microneedling Versus Carboxytherapy Either With or Without Platelet Rich Plasma in Treating Stria Distensae Rubra

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Jun 3, 2025
Registry last updated
Jun 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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