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OpenTrials
Completed

NCT Number: NCT07561671

PRP vs PRF in Management of Striae Distensae

A split-side comparative clinical study evaluating the efficacy and safety of injectable platelet-rich fibrin (PRF) versus platelet-rich plasma (PRP), alone or combined with microneedling, in the treatment of striae distensae. Thirty patients received PRF or PRP on one side and combination therapy with microneedling on the contralateral side over five sessions. Outcomes included striae width, length, severity score, and patient satisfaction

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Key information

Conditions

Striae Distensae Pathological Conditions, Signs and Symptoms Signs and Symptoms Skin Manifestations

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zagazig University Hospitals

Zagazig, Zagazig--, 44519, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults ≥18 years
  • Presence of striae distensae (rubrae or alba)
  • Willingness to participate and provide informed consent

Exclusion criteria

  • Keloid or hypertrophic scar tendency
  • Bleeding disorders or anticoagulant use
  • Pregnancy
  • Active skin infections (e.g., herpes, impetigo, tinea)
  • History of malignancy or collagen disease
  • Use of antineoplastic drugs
  • Conditions impairing wound healing
  • Unrealistic expectations

Treatment and study plan

PRF group

Biological

Autologous platelet-rich fibrin prepared via single-spin centrifugation without anticoagulant and injected intradermally

PRP injection

Biological

Intradermal injection of platelet-rich plasma

PRF and microneedling

Device

Performed using a dermapen device with 1 mm needle depth, followed by topical application of PRF.

PRP and microneedling

Device

Performed using a dermapen device with 1 mm needle depth, followed by topical application of PRP.

Primary outcomes

  1. The Imam, Nelva, Alviera score (INA score) (Change in striae severity)

    Time frame: baseline to 1 month after last session

    The INA score ranges from 0 to 54, with higher scores indicating greater striae distensae severity, therefore representing a worse outcome. Severity was categorized as mild for scores <21, moderate for scores 21-40, and severe for scores >40.

  2. Change in striae severity (Imam, Nelva, Alviera score (INA score)

    Time frame: 1 month after last session

    The INA score ranges from 0 to 54, with higher scores indicating greater striae distensae severity, therefore representing a worse outcome. Severity was categorized as mild for scores <21, moderate for scores 21-40, and severe for scores >40.

Sponsors and collaborators

Lead sponsor

Zagazig University

Other Gov

Registry information

Official study title

Split-Side Comparative Clinical Study of Platelet-Rich Fibrin Versus Platelet-Rich Plasma With or Without Microneedling in Treatment of Striae Distensae

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
May 1, 2026
Registry last updated
May 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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