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Completed

NCT Number: NCT01359033

MI Mortality Risk and Between-hospital Risk Variation in the United Kingdom and Sweden

The study aims to investigate the differences in survival trajectories and hospital variability in myocardial infarction (MI) mortality rates in the UK and Sweden.

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Key information

Age range

30 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Uppsala Clinial Research Center, Uppsala, Sweden

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About this study

Limited evidence is available in comparing hospital level care and reference mortality risks between countries, due to the scarce availability of nationwide coronary heart disease data. The demographics and medical expenditure percentage are comparable in the United Kingdom and Sweden; however, the in-hospital case-fatality rates within 30 days after admission for acute myocardial infarction was greater in the UK than Sweden (6.3% versus 2.9%)(OECD, 2009). To investigate the discrepancy, the current study aims to compare the mortality risk differences and associated explanatory factors between the two countries. Results of the study can contribute to myocardial infarction care implementation in the UK and Sweden.

The UK Myocardial Ischaemia National Audit Project (MINAP)and Register of Information and Knowledge about Swedish Heart Intensive care Admissions (RIKS-HIA) are few quality national registries currently available for acute coronary syndrome. Using data from the MINAP and RIKS-HIA, we propose to investigate (1)the survival trajectories for a reference patient with myocardial infarction and (2) hospital variability in myocardial infarction mortality rate in the UK and Sweden, adjusted for important patient-level and hospital-level covariates.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged above 30 years old who had hospital admission for acute myocardial infarction.
  • Admission period ranged from 1st January, 2004 to 31th December, 2008.

Exclusion criteria

  • Patients with missing data in the admission time and/or primary outcomes.

Treatment and study plan

Primary outcomes

  1. 30-day mortality

    Time frame: 30-day

    all-cause mortality at 30-day following hospitalization for acute Myocardial Infarction

Secondary outcomes

  1. 1-year mortality

    Time frame: 1 year

    all-cause mortality at 1-year following hospitalization for acute Myocardial Infarction

Sponsors and collaborators

Lead sponsor

University College, London

Other

Collaborators

  • MINAP: Myocardial Ischaemia National Audit Project
  • NICOR/MINAP, the United Kingdom
  • National Institute for Cardiovascular Outcomes Research
  • RIKS-HIA: Register of Information and Knowledge about Swedish Heart Intensive care Admissions
  • SWEDEHEART/RIKS-HIA, Sweden
  • SWEDEHEART: Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies

Registry information

Official study title

Compare the Patient Risk and Between-hospital Variation in Myocardial Infarction Mortality in the United Kingdom and Sweden

Important dates

Study start
2011
Primary completion
2013
Study completion
2014
First posted
May 24, 2011
Registry last updated
Nov 17, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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